Increased formation of reactive intermediates of oxygen reduction (superoxide O2-, hydrogen peroxide H2O2 and hydroxyl radical HO·) in diabetes may cause oxidative damage to proteins, lipids and nucleotides leading to chronic pathology. This has recently been linked to increased formation of peroxide from mitochondrial respiration.
- Antioxidants (vitamin E, vitamin C, lipoic acid)
- Divertors of reducing fluxes in mitochondria (high dose thiamine)
- Nishikawa,T., Edelstein,D., Liang Du,X., Yamagishi,S., Matsumura,T., Kaneda,Y., Yorek,M.A., Beede,D., Oates,P.J., Hammes,H.-P. et al. 2000. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemia damage. Nature 404:787-790.
Return to: Diabetic Complications Hypotheses page
Next page: Hypothesis on Depletion of NAD+