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Therapeutic Strategies

Prevention of activation of PKCβ

  • e.g. PKCβ inhibitor

Prevention of NAD+ depletion/metabolic pseudohypoxia

  • e.g. nicotinamide and aldose reductase inhibitors (ARIs)

Prevention of triosephosphate accumulation

  • e.g. high dose thiamine therapy

Prevention of the effects of glycation

  • α-Oxoaldehyde scavengers (aminoguanidine-like compounds)
  • Amadorins
  • RAGE antagonists - sRAGE and others

Prevention of oxidative stress

  • Vitamin E
  • Vitamin C
  • Lipoic Acid
  • Other thiol pool supplements

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