Molecular Cell Biology
Michael Smutny (Medical School & Centre for Mechanochemical Cell Biology): Cell & Developmental Biology: Studying biophysical and biochemical mechanisms that form and pattern the zebrafish embryo using live cell imaging, biophysical tools, genetics and transcriptomics. see: Smutny M. et al. Nat Cell Biol. 2017
Darius V. Köster (Centre for Mechanochemical Cell Biology) | Understanding the role of mechano-sensing and membrane tension regulation in cell-cell adhesion by using a combination of reconstituted, minimal systems, live cell experiments and controlled, mechanical micro-manipulations. | see: Köster and Mayor (2016), Current Opinion in Cell Biology, doi: 10.1016/j.ceb.2016.02.021.
Aparna Ratheesh(Medical School): Cell & Developmental Biology and Immunology. Mechanical and biochemical control of immune cell migration during embryogenesis using genetics, live-imaging, biophysical tools and modelling.I see : Ratheesh, A.et al. Developmental Cell. 2018 May 7;45(3).
Mohan Balasubramanian (Medical School) l Synthetic Cell Biology: Using biophysics and chemistry to understand molecular mechanisms of actomyosin ring dependent eukaryotic cell division l see: Huang et all, eLife, 2016.
Andrew Blanks (Medical School) l Reproduction in mammals, parturition and preterm birth, drug discovery, computational biology of bioelectrical systems l see: Jolene et al, PLOS Computational Biology, 2016.
Andrew Bowman (Medical School) l Research utilises novel synthetic biology approaches and fluorescence microscopy to observe chromatin assembly in living cells l see: Bowman et al, Nucleic Acids Res., 2016.
Mark Christian (Medical School) l Understanding the processes that control energy metabolism in brown adipocytes and have the potential to be targeted for weight loss treatments l see: Barneda et al, eLife, 2015.
Robert Dallmann (Medical School) l Circadian clocks in health, disease and pharmacotherapy l see: DeBruyne JP et al, 2014.
Geraldine Hartshorne (Medical School) l Human oocyte formation, selection, maturation and ageing; pre-implantation embryo development l see: Patel et al, Biology Open, 2015.
Andrew McAinsh (Centre for Mechanochemical Cell Biology) l Origins of chromosome mis-segregation in human disease and development, live-cell imaging, in vitro reconstitution, genome editing, image analysis l see: Smith et al, eLife, 2016.
Jonathan Millar (Centre for Mechanochemical Cell Biology) l The Millar lab studies the mechanism and deregulation of cell cycle checkpoints using live cell imaging, image analysis, phospho-proteomics, bioinformatics and genome editing in yeast and human cells l see: Mora-Santos et al, Current Biology, 2016.
Masanori Mishima (Medical School) l Molecular mechanisms of animal cytokinesis l see: Lee et al, Nat. Comms 6:7290, 2015.
Giacomo de Piccoli (Medical School) l How the S phase checkpoint regulates the replication machinery l see: Garcia-Rodriguez LJ et al, Nucleic Acids Res., 2015.
Steve Royle (Centre for Mechanochemical Cell Biology) l Mitotic spindle stability in human cells; molecules and mechanics of clathrin-mediated endocytosis l see: Nixon et al, eLife 4:e07635, 2015.
Karuna Sampath (Medical School) l Molecular mechanisms that control development and differentiation in embryonic progenitors using live-imaging, proteomics, genome editing, quantitative approaches and zebrafish developmental genetics l see: Yin et al, eLife 5:e13879, 2016.
Anne Straube (Centre for Mechanochemical Cell Biology) l Mechanisms of microtubule organisation and dynamics regulation; microtubule functions in cell differentiation and migration l see: Mogessie et al, eLife, 2015.
Mark Achtman (Medical School) l Reconstruction of the evolutionary history of bacterial pathogens by combining ancient DNA analyses with population genetics of extant organisms l see: Zhou et al, PNAS, 2014.
Chrystala Constantinidou (Medical School) l Microbial pathogenesis through the study of secretion systems, motility and genomics analysis l see: Loman et al, JAMA, 2013.
Meera Unnikrishnan (Medical School) l Understanding how clinically important bacterial pathogens colonise the host, invade and survive within host cells using a combination of whole genome-based and cellular methodologies l see: Dapa et al, J. Bacteriol., 2013.
Nick Waterfield (Medical School) l Understanding the molecular mechanisms employed by bacterial pathogens to achieve virulence in insect and human hosts, more specifically how certain insect pathogens have evolved to infect humans also. l see: Mulley et al, PLoS One, 2015.
A*STAR Research Institutes (Singapore)