Four-year fully funded studentships available for 2021 entry
These studentships offer the opportunity of PhD research into the ways in pathogenic bacteria and viruses emerge, evolve and spread, deploy the structures and strategies needed for survival within host cells and tissues and how these vary across populations with the emergence of anti-microbial resistance (AMR). Jointly supervised by internationally leading experts from biomedicine, engineering and the physical sciences, this programme will enable you to integrate molecular, quantitative and analytical approaches to undertake important new discovery science projects in molecular microbiology and infection.
- Exceptional Bioinformatics infrastructure through the MRC CLIMB project.
- State-of-the art facilities for genomics, protein purification and a Research Technology Platform in Proteomics.
- Warwick Antimicrobial Interdisciplinary Centre (WAMIC).
- The Zeeman Institute for Systems Biology and Infectious Disease Epidemiology (SBIDER)
- Munehiro Asally (Life Sciences) l Collective dynamics of bacterial colonies (biofilms, swarming), bacterial electrophysiology, fluorescent time-lapse microscopy. / see: Asally et al, PNAS, 2012 l working with: Marco Polin (Physics), Vasily Kantsler (Physics), Sara Kalvala (Computer Science).
- Greg Challis (Chemistry) l The discovery, biosynthesis, bioengineering and mechanism of action of antibiotics and other bioactive specialised metabolites produced by microorganisms. l see: Rutledge and Challis, Nature Reviews Microbiology, 2015. l working with: Jozef Lewandowski (Chemistry), Christopher Corre (Life Sciences/Chemistry).
- Erin Connelly (Life Sciences) l Antimicrobial discovery from natural products inspired by ingredients from historical medical recipes l see: Connelly et al, mBio 2020 l working with Freya Harrison (Life Sciences)
- Allister Crow (Life Sciences) l Structural studies of bacterial proteins. Interested in how bacteria divide, cause infections, and defend themselves against antibiotics. | See: Crow et al PNAS 2017.
- Samuel Dean (WMS) l Ciliary function in protozoan parasite pathogenicity and human genetic disease l see Dean et al. eLife 2019 PMID30810527 l My work intersects with that of Ann Straube and Robert Cross.
- Marcio Dias (Chemistry) l Understanding the cell biosynthesis and remodeling in Mycobacterium tuberculosis using a structural biology perspective through crystallography. We are also interested in drug discovery methods, particularly fragment-based drug discovery (FBDD) and drug repurposing. l see Dias et al. ACS Infect Dis. 2019 l working with Liz Fullam (Life Sciences) and Manuela Tosin (Chemistry).
- Ann Dixon (Chemistry) l Molecular and structural basis of membrane protein folding and interactions for proteins of importance to immune function and development of disease. l see: Nash et al, BBA Biomembranes, 2015 l working with: Victor Zammit, Mark Christian, Daniel Mitchell, Judith Klein-Seetharaman (Medical School), Lorenzo Frigerio, David Roper (Life Sciences), Steven Brown (Physics), Daniel DiMaio, James Drake (USA).
- Christopher Dowson (Life Sciences) l Antibiotic discovery and antibiotic resistance: underpinned by fundamental mechanistic insight using molecular microbiology, biochemistry, and high resolution imaging.
- Elizabeth Fullam (Life Sciences) l Utilising a multidisciplinary approach to understand nutrient uptake and metabolism in Mycobacterium tuberculosis. l see: Fullam et al, Open Biology, 2016 l working with: Matthew Gibson (Chemistry), Alison Rodger (Chemistry).
- Matthew Gibson (Chemistry) l Developing systems for rapid, low cost microbial diagnostics (for e.g developing countries); understanding the role of carbohydrates in infection; cryopreseration of donor cells/tissue inspired by how antifreeze proteins enable life to flourish in the polar oceans. l see: Deller et al, Nature Communications, 2014 l working with: Nick Waterfield, Daniel Mitchell (Medical School), Elizabeth Fullam (SLS).
- Freya Harrison (Life Sciences) | Pathogenesis and antibiotic resistance of bacterial biofilms in chronic lung infection; antibiotic discovery from natural products used in historical medicine. | see: Harrison et al, mBio, 2015 l working with Meera Unnikrishnan (Medical School), Julie Bruce (Clinical Trial Unit), Dowson/Roper groups (Life Sciences), Dave Barrett (Pharmacology, Nottingham), Kendra Rumbaugh (Surgery, Texas Tech).
- Matthew Jenner (Chemistry) | Mapping protein-protein interactions in biosynthetic systems responsible for antibiotic production using structural mass spectrometry. | See: Jenner et al. 2018. Nat. Chem. Biol., 14, 270-275. | Working with Jozef Lewandowski (Chemistry), Greg Challis (Chemistry).
- Vasily Kantsler (Physics) l Biophysics and physiology of bacterial chemotaxis using microfluidics and optical microscopy methods. l see: Bukatin et all, Proc. Natl. Acad. Sci. USA, 2015 l working with: Munehiro Asally, Andre Pires da Silva (Life Sciences).
- Fayyaz Minhas (Computer Science) l I work on the development of bespoke machine learning models in computational biology and pathology l Eitzinger, Simon, Amina Asif, Kyle E. Watters, Anthony T. Iavarone, Gavin J. Knott, Jennifer A. Doudna, and Fayyaz ul Amir Afsar Minhas. “Machine Learning Predicts New Anti-CRISPR Proteins.” Nucleic Acids Research. April 16, 2020. https://doi.org/10.1093/nar/gkaa219 l collaborating with Nasir Rajpoot (Computer Science)
- Bridget Penman (Life Sciences) l Uses co-evolutionary theory to understand how human genetics affects infectious disease severity. Studies the genetics of malaria resistance, and HLA and KIR genetics. l Penman et al PNAS 2013, PMID 24225852.
- Nicole Robb (WMS) l An interdisciplinary approach to understanding how viruses replicate and development of rapid optical viral diagnostic tests l See: Robb et al., Scientific Reports, 2019. doi: 10.1038/s41598-019-52759-5
- Rudo Roemer (Physics) l Research interests in protein rigidity and flexibility as applied to structure and function relations in systems/problems such as HIV protease, PDI, AMR resistance, ligand-binding, etc. Also, electron transport in biological molecules including DNA. l See: Soulby et al, Protein Sci., 2015 l working with: Chris Dowson, David Roper, Robert Freedman (Life Sciences).
- David Roper (Life Sciences) | Investigating the molecular basis of microbial physiology in relation to antimicrobial resistance.
- Phill Stansfeld (Life Sciences) | Structural bioinformatics and molecular dynamics simulations to understand fundamental and potentially druggable pathways within the bacterial cell envelope.
- Anne Straube (Medical School) | Viral hijacking of the host cytoskeleton using Marek's disease virus as model system to study changes in microtubule and actin organisation and mechanism of viral capsid transport. | see: Theisen et al, Dev Cell 2012 | working with: Venugopal Nair (Pirbright).
- Manuela Tosin (Chemistry) l Chemical biology tools for the elucidation of antibiotic biosynthesis; understanding the role of glycosyltransferase enzymes in health and disease l see: Riva et al., Angew Chem Int Ed Engl. 2014 l working with: Christopher Corre (Life Sciences/Chemistry), Jozef Lewandowski (Chemistry), Alex Cameron (Life Sciences), Alex Jones (Life Sciences), Rachel O'Reilly (Chemistry).
- Meera Unnikrishnan (Medical School) | Understanding how clinically important bacterial pathogens colonise the host, invade and survive within host cells using a combination of whole genome-based and cellular methodologies. | see: Dapa et al J. Bacteriol., 2013 | working with: Marco Polin (Physics) and Chris Corre (Chemistry).
- Nick Waterfield (Medical School) l Understanding the molecular mechanisms employed by bacterial pathogens to achieve virulence in insect and human hosts, more specifically how certain insect pathogens have evolved to infect humans also. l see: Mulley et al PLoS One, 2015 l working with: Matthew Gibson, Peter Scott (Chemistry), Christopher Corre, David Roper (Life Sciences).