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Life Sciences seminar by Prof. Marietta Zille, University of Vienna

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Speaker: Prof. Marietta Zille, University of Vienna. Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology

Title: ‘Intracerebral hemorrhage: Beyond the neuron’ 

Intracerebral hemorrhage (ICH) remains a major cause of mortality and permanent disability. Targeting primary injury by removing the hematoma has been of limited success and a complete evacuation of the hematoma is unlikely to be achieved in every patient. It is clear that clot-derived factors such as hemoglobin and heme are major contributors to secondary tissue damage. Recently, we and others have described the mechanisms underlying neuronal cell death exposed to blood breakdown products. However, it is unlikely that targeting neurons alone will suffice to successfully treat ICH patients. Hence, elucidating the pathophysiological mechanisms in other brain cells and their potential to contribute to reducing brain damage is crucial for the development of novel combinatorial therapeutic approaches. In this seminar, the mechanisms underlying axonal degeneration and brain endothelial cell death after ICH will be described. Furthermore, at the time of diagnosis, a significant number of brain cells is already irreversibly lost and the regenerative potential is rather low due to limited neurogenesis and the detrimental environment post-ICH. Our efforts to better understand the etiology of ICH in order to develop innovative model systems and therapeutic approaches that will enable the timely prevention and treatment of ICH and other cerebrovascular diseases will be discussed.


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