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BCB Seminar: Dr Miho Katsuki

At a Glance
Date: 25 April 2012
Time: 2-2.30pm
Location: T0.08, Clinical Trials Unit, Warwick Medical School
Open To: Staff and students
Cost: Free
Summary:

Dr Miho Katsuki, Research Fellow, Biomedical Cell Biology Division, University of Warwick will present this seminar on ‘Dynamics Of A-Lattice Microtubules’.

Dr Miho Katsuki, Research Fellow, Biomedical Cell Biology Division, University of Warwick will present this seminar on ‘Dynamics Of A-Lattice Microtubules’.

Abstract

Microtubules are intrinsically dynamic structures whose polymerisation is subject to extensive spatial and temporal control in cells, partly through the activity of microtubule-associated proteins. Microtubules can potentially assemble with two different lattice arrangements of heterodimers. Lateral contacts of heterodimer subunits may be either alpha-beta, making an A-lattice, or alpha-alpha and beta-beta, forming a B-lattice. 13-protofilament B-lattice microtubules contain a single seam of A-lattice contacts. A-lattice microtubules are composed purely of these seams. Since microtubules assembled in vitro have predominantly the B-lattice arrangement, it has not previously been possible to study the dynamics of the A-lattice.

It was recently discovered that Mal3, the EB1-homologue in S. pombe, stabilises the A-lattice and promotes assembly of 13-protofilament A-lattice-containing microtubules. Research is now underway to analyse the dynamics of Mal3-induced A-lattice microtubules in vitro.

Further information

All staff and students are welcome and there is no need to register in advance. If you have any queries, please contact Gemma Wild at G dot Wild at warwick dot ac dot uk

This research seminar is part of the Biomedical Cell Biology Seminar series, presented by the Division of Biomedical Cell Biology, Warwick Medical School.