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Does size matter? Placenta debris and the pathophysiology of Pre-eclampsia

At a Glance
Date: Thursday 8 December
Time: 12:30pm to 1:30pm
Location: Clinical Sciences Research Laboratories
Open To: Staff and students
Cost: Free
Summary: A seminar by Professor Ian Sargent on 'Does size matter? Placenta debris and the pathophysiology of pre-eclampsia'.

Professor Ian Sargent, Professor of Reproductive Medicine, Nuffield Department of Obstetrics and Gynaecology, will present this seminar on 'Does size matter? Placenta debris and the pathophysiology of pre-eclampsia'.

Abstract

During pregnancy the placental syncytiotrophoblast releases a range of cellular debris including microvesicles and exosomes (50-1000nm) into the maternal circulation, with increased amounts in pre-eclampsia. These vesicles are proinflammatory and cause endothelial dysfunction; two defining features of this disease. We have used a novel technology, nanoparticle tracking analysis, together with flow cytometry, proteomics and miRNA arrays to begin to characterise vesicles and determine their roles in normal pregnancy and pre-eclampsia.

Further information

Transport will be provided from the Medical Teaching Centre at Gibbet Hill to the Clinical Sciences Research Laboratories at University Hospital Coventry and Warwickshire. For details please contact Kimberley Thomas at kimberly dot thomas at warwick dot ac dot uk.

The seminar series is presented by Warwick Medical School's Division of Reproductive Health.