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CH3F8 - Advanced Coordination and Bio-Inorganic Chemistry

  • Module code: CH3F8
  • Module name: Advanced Coordination and Bio-Inorganic Chemistry
  • Department: Chemistry
  • Credit: 15

Content and teaching | Assessment | Availability

Module content and teaching

Principal aims

This module will examine the ways in which biological systems use the specific chemical properties offered by the full range of elements in the periodic table {including f-block elements} to perform a wide variety of functions. The module will introduce the chemical principles that govern the use of essential metal ions in biological systems, and selected examples will be discussed, to illustrate these principles. The impact of bio-inorganic chemistry on human health will be discussed in both the context of the consequences of aberrations in metal ion housekeeping and the use of metallo-based drugs.

Principal learning outcomes

By the end of the module the student should be able to: Understand and rationalise roles that essential metal ions play in biological systems: Control of protein structure and dynamics, enzymatic catalysis, signalling. Understand the rationales for the selection of metal ions to perform biological functions Identify metal-binding portions of biomolecules, recognise and describe the differences between metal sites in small molecule complexes and proteins. Understand the principles of metal ion homeostasis: metalloregulation of gene expression and translation, metal ion transport through membranes and cytosols Understand and rationalise the effects that the binding of metal ions to proteins and nucleic acids has on the structure and dynamics of biomolecular structures. Understand and rationalise the mode of actions of metal ions in hydrolytic and redox metalloenzymes. Understand and rationalise the impact of metal binding residues and protein environment (coordination numbers and geometry, hydrophobic and electrostatic effects) on reactivity of metal ions Understand and rationalise the mode of action and design features of selected metallodrugs

Timetabled teaching activities

22 Lectures 4 hours workshops/example classes 2hrs revision

Departmental link

http://go.warwick.ac.uk/CH3F8

Other essential notes

Pre-requisite s: CH267

Module assessment

Assessment group Assessment name Percentage
15 CATS (Module code: CH3F8-15)
B (Examination only) Examination - March 100%
Assessed Course Work 100%

Module availability

This module is available on the following courses:

Core

N/A

Optional Core

N/A

Optional
  • Undergraduate Biomedical Chemistry with Intercalated Year (B9F1) - Year 4
  • Undergraduate Biomedical Chemistry (BF91) - Year 3
  • Undergraduate Chemistry 3 Year Variants (F100) - Year 3
  • Undergraduate Chemistry (with Intercalated Year) Variants (F101) - Year 4
  • Undergraduate Master of Chemistry Variants (F105) - Year 3
  • Undergraduate Master of Chemistry Variants (F106) - Year 3
  • Undergraduate Master of Chemistry (with Intercalated Year) (F107) - Year 3
  • Undergraduate Master of Chemistry (with Intercalated Year) (F107) - Year 4
  • Undergraduate Chemistry 3 Year Variants (F121) - Year 3
  • Undergraduate Chemistry (with Intercalated Year) Variants (F122) - Year 4
  • Undergraduate Master of Chemistry Variants (F125) - Year 3
  • Undergraduate Master of Chemistry Variants (F126) - Year 3
  • Undergraduate Master of Chemistry with Medicinal Chemistry(with Intercalated Year) (F127) - Year 3
  • Undergraduate Master of Chemistry with Medicinal Chemistry(with Intercalated Year) (F127) - Year 4
  • Undergraduate Chemical Biology MChem with Intercalated Year (F1C1) - Year 3
  • Undergraduate Chemical Biology MChem with Intercalated Year (F1C1) - Year 4
  • Undergraduate Chemistry with Management (F1N1) - Year 3
  • Undergraduate Chemistry with Management (with Intercalated Year) (F1N2) - Year 4
  • MChem Chemical Biology (FC11) - Year 3