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BS979 - Drug Discovery and Biopharmaceutical Development

  • Module code: BS979
  • Module name: Drug Discovery and Biopharmaceutical Development
  • Department: School of Life Sciences
  • Credit: 20

Content and teaching | Assessment | Availability

Module content and teaching

Principal aims

To allow students the opportunity to study the fundamental principles of drug discovery and biotechnology. Students will develop a detailed knowledge of the potential for drug discovery and exploitation by the pharmaceutical industry and a critical appreciation of some of the various techniques in use. Students will acquire an integrated understanding of the breadth and depth of medicianal drug design and productions. The module also extends the knowledge base relevant to the development and exploitation of biopharmaceutical products by the pharmaceutical industry. Students will integrating of the information presented with the core ethos of the programme by addressing issues concerned with the regulation of pre-clinical and clinical trials, through the Regulatory Procedures of development of biopharmaceuticles into a commercial reality.

Principal learning outcomes

Students will: Have a broad, integrated knowledge of drug discovery and biopharmaceuticals and respective industries. Be able to critically assess the use of novel drug design techniques and their risk to the pharmaceutical industry Be able to demonstrate knowledge of drug and biopharmaceutical development for the treatment of common and rare diseases Be able to critically assess the commercial advantages and disadvantages when selecting a new drug target

Timetabled teaching activities

Lectures; Seminars; Workshop; Case Studies; Group Work

Other essential notes

The fundamental principles of drug discovery for medicinal gain. The process of drug discovery using molecular biology and genetic engineering. Recent advances in drug discovery, rational drug design, biological principles and detailed consideration of the research and development. Examples with proven exploitation whilst also addressing the limitations (and dangers) of the drug technologies and their commercial potential. Biopharmaceutical products: proteins, viruses, gene and cell therapy, vaccines. Commercial exploitation: markets, diseases, companies. Cell substrates: Mammalian/bacterial/fungal/insect. Cell bank manufacture and testing Development of a biopharmaceutical: Stages in development from pre-clinical safety studies through Phase I – II – III – IV clinical studies. Regulatory Agencies; procedure, policies and guidelines. Chemistry, Manufacture and Control (CMC). Good Manufacturing Practice and Quality Assurance: Manufacture: Processes for extracting, purifying, formulating and filling. Process validation and qualification. Products: Vaccines, Advanced Therapy Medicinal Products, Biosimilars

Module assessment

Assessment group Assessment name Percentage
20 CATS (Module code: BS979-20)
A (Assessed work only) Individual Poster 40%
  Case Study Presentations 60%

Module availability

This module is available on the following courses:

Core
  • Postgraduate Taught Biotechnology, Bioprocessing and Business Management (C5N2) - Year 1
  • Postgraduate Medical Biotechnology and Business Management (J7N2) - Year 1
Optional Core
  • Postgraduate Medical Biotechnology and Business Management (J7N2) - Year 2
Optional

N/A