WMS » Recent Developments in the Patho-Physiological Molecular Clocks Lab (tag [2020])

Did we wake up in time for better stroke treatment translation?

Fri, 18 Dec 2020 14:00:00 GMT

In a commentary led Warwick colleague Johannes Boltze and Nadine Diwischus and Munich researchers Martha Merrow and Nikolaus Plesnia in the Journal of Cerebral Blood Flow and Metabolism, we argue that recent discoveries on the considerable circadian modulation of treatment in stroke might explain some of translational failures in therapeutic development in this area.

FY26 a new Osmium complex to treat cancer

Fri, 11 Dec 2020 10:00:00 GMT

Led by Swati Kumar and in collaboration with the Sadler, Perrier and Lévi groups, we investigated the chronotherapy with novel organo-osmium complex [Os^II(ɳ⁶-p-cym)(PhAzPy-NMe₂)I]⁺ (FY26), and show that FY26 exhibits promising in vitro antitumour activity against mouse hepatocarcinoma Hepa1-6 and other mouse or human cancer cell lines. Here, we drastically enhance water solubility of FY26 through the replacement of the PF₆⁻counter-anion with chloride using a novel synthesis method. FY26.PF₆ and FY26.Cl displayed similar in vitro cytoxicity in two cancer cell models. We then show the moderate and late anticancer efficacy of FY26.PF₆ and FY26.Cl in a subcutaneous murine hepatocarcinoma mouse model. Both efficacy and tolerability varied according to FY26 circadian dosing time in hepatocarcinoma tumour-bearing mice. Tumour and liver uptake of the drug were determined over 48 h following FY26.Cl administration at Zeitgeber 6 (ZT6), when the drug is least toxic (in the middle of the light span when mice are resting). Our studies suggest the need to administer protracted low doses of FY26 at ZT6 in order to optimize its delivery schedule, for example through the use of chrono-releasing nanoparticles.

Covid Chocolate Calendar Alert

Tue, 01 Dec 2020 20:22:45 GMT

As 2020 is drawing to a close we take comfort in some well dosed daily chocolate. Advent calendars as standard issue for all doctoral students in the lab.

Looking for an opportunity to write an application for a 2-year EU funded ISF-EUTOPIA post-doctoral fellowship (MSCF)?

Tue, 01 Dec 2020 11:24:33 GMT

If you are interested in working with us in collaboration with Damiana Rozman at the University of Ljubljana in Slovenia and us in Warwick.

We are looking for candidates of any nationality that have not lived in the UK (or alternatively, not in the Slovenia) for the past 3 years (MSCF mobility rules apply) with a PhD in biosciences. Experience in 3D cell culture and an interest in circadian clocks and cancer would be a great asset.

Please do get in touch ASAP!

BSN project award for Lauren to further characterise a novel tissue-specific bioluminescence reporter model

Fri, 02 Oct 2020 17:00:00 GMT

We are thankful to the British Society for Neuroendocrinology for supporting Lauren's work to characterise a novel circadian reporter model and develop new strategies for recording tissue level bioluminescence data from freely behaving animals.

Welcome (back) to the lab Rachael

Thu, 24 Sep 2020 14:40:26 GMT

After a summer project on clocks in 2019, Rachael returns for her master project in which she will tackle a novel clock in a different kind of cell in a collaborative project with Sam Dean (WMS).

Warwick-Wellcome Translational Project Funding

Thu, 24 Sep 2020 14:35:36 GMT

Together with Seb Perrier (Chemistry/WMS), Alexia Hapeshi (WMS/Chemistry) and Meera Unnikrishnan (WMS), we have received pump priming funding to develop novel materials to develop antituberculosis (TB) treatments.

Research Fellow position available in interdisciplinary CRUK funded project!

Mon, 09 Mar 2020 14:17:03 GMT

In a collaborative project with David Rand and Robert Dallmann, we are looking for a Post-Doctoral Research Fellow in a project on mathematical and machine-learning analysis of circadian effects on cancer outcome.

You should have a strong background in mathematics, statistics, computer science, physics or engineering and a some knowledge of data analysis and mathematical modelling. If you like to interact with circadian biologists then do not hesitate to get in touch.

Please read the complete advertisement here.

Polymer Nanoparticles for Drug Discovery - Collaboration with Perrier and Sadler labs

Tue, 03 Mar 2020 13:17:00 GMT

Very happy to answer questions on my #RSCPoster #RSCPoster2020 #RSCNano #RSCMat pic.twitter.com/OeymP5IsNU
— RAERichardson (@rae_richardson) March 3, 2020

Our review cited in a video explaining chronotherapy!

Mon, 20 Jan 2020 22:38:00 GMT