WMS » Publications (tag [2019])

Review on how stress increases the susceptibility to herpes simplex virus type 1 primary and recurrent infections

Sun, 21 Jul 2019 21:21:02 GMT

Following primary infection, HSV-1 establishes latency and reactivates under stress. Stress disturbs inner immune Yin–Yang balance, increasing the susceptibility to HSV-1 infection. In latent infection, stress induces changes in hormone level, chromosomal modification and oxidation, thereby disturbing the Yin–Yang balance between HSV-1 and the host defense, leading to recurrent diseases.

Pgp expression is modulated by the circadian clock, food intake and sex

Sun, 21 Jul 2019 21:01:11 GMT

Co-lead author Swati A. Kumar in a collaboration with Annabelle Ballesta, Alper Okyar, Francis Lévi, Enza Piccolo and us entitled: Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling, we described how time-of-day of drug administration might lead to different pharmacokinetic profiles in male and female mice.

Alper Okyar, Swati Kumar, Elisabeth Filipski, Enza Piccolo, Narin Ozturk, Helena Xandri-Monje, Zeliha Pala, Kristin Abraham, Ana Rita Gato de Jesus Gomes, Mehmet N. Orman, Xiao-Mei Li, Robert Dallmann, Francis Lévi, Annabelle Ballesta, Scientific Reports, 2019, DOI: 10.1038/s41598-019-46977-0

Hyperbranched poly(ethylenimine-co-oxazoline) by thiol-yne chemistry for non-viral gene delivery:investigating the role of polymer architecture

Fri, 01 Feb 2019 21:12:00 GMT

Happy to have been able to help out for this interesting new paper looking into new ways of transfecting cells.