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BEGIN:VEVENT
DTSTAMP:20260410T041504Z
DTSTART;VALUE=DATE-TIME:20100224T130000
DTEND;VALUE=DATE-TIME:20100224T140000
SUMMARY:Complexity Forum - Martin Weigt
TZID:Europe/London
UID:20100224-094d43d5385c299a01386c3bd8b36e00@warwick.ac.uk
CREATED:20100110T221243Z
DESCRIPTION:Speaker: Martin Weigt (ISI Torino) Title: Inference of protei
 n-protein interactions from multi-species sequence data using statistica
 l-physics inspired approaches Abstract: Experimental approaches to trans
 ient protein interactions are laborious and serendipitous\, and our unde
 rstanding of fundamental questions like the identification of interactio
 n surfaces or the specificity of molecular recognition between interacti
 ng proteins are far from being solved. We propose a computational approa
 ch based on recent techniques from the statistical physics of disordered
  systems\, which exploits the natural sequence variability of homologous
  proteins across hundreds of species species. Using bacterial two-compon
 ent signal transduction (TCS) as a test case\, we show that our method i
 s able (i) to identify inter-protein residue contacts and to facilitate 
 the prediction of protein complex strutures\, and (ii) to reconstruct a 
 molecular recognition code which elucidates specificity in signal transd
 uction in bacteria. [M. Weigt\, R.A. White\, H. Szurmant\, J.A. Hoch\, T
 . Hwa\, "Identification of direct residue contacts in protein-protein in
 teraction by message passing"\, Proc. Natl. Acad. Sci. 106\, 67 (2009).]
 
LOCATION:
CATEGORIES:Seminar Room D1.07,forum
LAST-MODIFIED:20120709T145408Z
ORGANIZER;CN=Colm Connaughton:
END:VEVENT
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