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BEGIN:VEVENT
DTSTAMP:20260410T135335Z
DTSTART;VALUE=DATE-TIME:20121121T130000
DTEND;VALUE=DATE-TIME:20121121T140000
SUMMARY:Complexity Forum: Thomas Fink (Institut Curie)
TZID:Europe/London
UID:20121121-094d43d5385c299a01386c3bd8da771c@warwick.ac.uk
CREATED:20120329T091422Z
DESCRIPTION:Speaker: Thomas Fink (Curie Institute) Title: Is the theory o
 f neutral evolution right? Abstract: The neutral theory of evolution sta
 tes that the vast majority of mutations are selectively neutral (they do
  not affect fitness). This was put forth three decades ago\, and it rema
 ins the conventional view that nearly all mutations preserve phenotype. 
 The fraction of mutations in a population that are neutral is the phenot
 ype robustness r. Just how high can r be? We prove\, using spectral grap
 h theory\, that the robustness r is severely limited by the size s of it
 s underlying neutral network. It means that robust phenotypes must have 
 vast neutral networks\, and that high values of robustness may not be bi
 ologically possible. We confirm our result by exact enumeration of neutr
 al networks for short sequences\, by random sampling for longer sequence
 s\, and using data from RNA molecules and the genetic code. Lunch group:
  2
LOCATION:D1.07
CATEGORIES:forum
LAST-MODIFIED:20120709T145410Z
ORGANIZER;CN=Karen McKinley:
END:VEVENT
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