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BEGIN:VEVENT
DTSTAMP:20260409T180804Z
DTSTART;VALUE=DATE-TIME:20170315T130000
DTEND;VALUE=DATE-TIME:20170315T140000
SUMMARY:Seminar: New aspects of cell polarity control in fission yeast\, 
 Professor Kenneth Sawin\, School of Biological Sciences\, University of 
 Edinburgh
TZID:Europe/London
UID:20170315-094d43f55969508901596f3a941c3e0b@warwick.ac.uk
CREATED:20170105T152347Z
DESCRIPTION:Abstract: Fission yeast are highly polarised\, cylindrical ce
 lls that grow by new membrane deposition and cell wall synthesis exclusi
 vely at cell tips. I will describe two stories about our recent work on 
 cell polarity regulation in this model eukaryote. One story concerns our
  discovery that Sty1\, a MAP kinase in the conserved stress-activated pr
 otein kinase pathway\, is a key regulator of the cell polarity module co
 ntrolled by the Rho-family small GTPase Cdc42. As part of this we develo
 ped a novel system that allows us to reversibly switch on Sty1 kinase ac
 tvity in the complete absence of external stress. The other story concer
 ns internal cues/landmarks that determine which tips of newly-born daugh
 ter cells will be chosen as growth sites after septation. We have found 
 that three different internal cues collaborate and compete to regulate p
 atterns of polarised growth in daughter cells. One of these cues is a no
 vel “growth-memory” cue\, which remembers prior growth history during ti
 mes of no growth—essentially an epigenetic phenomenon\, in the older sen
 se of the term “epigenetic”. We are beginning to address the molecular n
 ature of this growth-memory cue.
LOCATION:GLT2\, Medical School Building
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20170208T154118Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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