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BEGIN:VEVENT
DTSTAMP:20260408T234636Z
DTSTART;VALUE=DATE-TIME:20200603T130000
DTEND;VALUE=DATE-TIME:20200603T140000
SUMMARY:Virtual BMS Divisional Seminar: Quantifying the nanoscale organis
 ation of the T cell immunological synapse\, Professor Dylan Owen\, Insti
 tute of Immunology and Immunotherapy\, University of Birmingham
TZID:Europe/London
UID:20200603-8a1785d771405cd10171a61c685b5e49@warwick.ac.uk
CREATED:20200603T115502Z
DESCRIPTION:Abstract: CD4 positive Helper T cells form an essential compo
 nent of the adaptive immune response. As such\, they are required to act
 ivate when required - to ward off infection\, and remain inactive when c
 onfronted with the body’s own tissues – to avoid autoimmune disease. It 
 is now known that a mechanism partly responsible for this tight regulati
 on is nanoscale protein spatio-temporal organization\, especially the na
 noclustering of surface proteins. Here\, I will outline my lab’s latest 
 work on quantifying the nanoscale organization of protein using super-re
 solution microscopy via single molecule localization microscopy (SMLM). 
 In particular\, I will focus on many-colour quantitative statistical clu
 ster analysis and stochastically accurate DNA-PAINT imaging. These are a
 pplied to a negative regulating pathway involving Csk\, TRAF3 and PAG wh
 ich is relevant to autoimmune diseases including rheumatoid arthritis\, 
 lupus and diabetes. I will also outline out latest work analysing the sp
 atial organization of membrane lipids using environmentally-sensitive li
 pid probes and advanced microscopy.
LOCATION:via Zoom
CATEGORIES:BiomedicalSciences,BMS_CDB
LAST-MODIFIED:20200603T115502Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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