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BEGIN:VEVENT
DTSTAMP:20260413T011432Z
DTSTART;VALUE=DATE-TIME:20220712T150000
DTEND;VALUE=DATE-TIME:20220712T160000
SUMMARY:BMS Seminar: Complex waves on the surface of live cells: A new pa
 ttern formation paradigm\, Professor Andrew Goryachev\, Professor of Com
 putational Cell Biology\, University of Edinburgh
TZID:Europe/London
UID:20220712-8a1785d780d13da50180d612bb600eb1@warwick.ac.uk
CREATED:20220606T082802Z
DESCRIPTION:Abstract: Biochemical oscillations that emerge from the inter
 play of fast positive and delayed negative feedbacks can produce propaga
 ting waves in spatially extended systems. Recently\, we described actin 
 waves on the cortex of large (~1000 µm) cells\, oocytes and embryos of f
 rogs and echinoderms\, and demonstrated that they are driven by the wave
 s of activity of small GTPase Rho\, a signaling molecule known to patter
 n the cytokinetic furrow (Bement et al.\, Nat. Cell Biol. 17:1471\, 2015
 ). A new breakthrough in this project has been precipitated by the intro
 duction of the genetically rewired frog oocytes\, in which the concentra
 tions of molecules responsible for positive and negative feedback can be
  varied at will. This technical advance produced high-quality imaging da
 ta revealing oscillatory wave patterns with the complexity and diversity
  unprecedented in any in-vivo system and rivaling those of the establish
 ed in-vitro paradigms\, such as the Belousov-Zhabotinsky reaction and th
 e MinDE system. Furthermore\, I show that our model is able to predict h
 ow the experimental parameters control the succession of patterns and ex
 plain their characteristic defects and instabilities. I will show how ex
 periment and theory can synergize to provide understanding of a dramatic
  oscillatory phenomenon as well as shed light on the underlying function
 al cellular mechanisms. Biography: Andrew is a computational cell biolog
 ist with a multifaceted experience and broad interest in cellular morpho
 genesis and pattern formation. A major focus of research in his group is
  on the biophysical mechanisms of symmetry breaking. Andrew obtained his
  PhD in modeling pattern-formation in complex chemical systems from the 
 University of Toronto\, Canada. Since then he has been working on the in
 terface of Biology\, Chemistry and Physics in academic\, industrial and 
 governmental settings. He joined University of Edinburgh in 2006 and is 
 now a Professor of Computational Cell Biology at the Centre for Syntheti
 c and Systems Biology\, Institute for Cell Biology\, School of Biologica
 l Sciences.
LOCATION:IBRB lecture theatre and via MS Teams
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20220606T082802Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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