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BEGIN:VEVENT
DTSTAMP:20260415T235614Z
DTSTART;VALUE=DATE-TIME:20190128T130000
DTEND;VALUE=DATE-TIME:20190128T140000
SUMMARY:Csilla Varnai (Babraham Institute\, Cambridge)
TZID:Europe/London
UID:20190128-8a1785d86850d8d901689fbed0ef462c@warwick.ac.uk
CREATED:20190121T091926Z
DESCRIPTION:Modelling of Chromosome Structure and Function Chromosomes\, 
 contrary to the popular view of the X-shaped structure\, most of the tim
 e look more like a tangled spaghetti soup. Different cell types\, such a
 s muscle\, liver and stem cells\, share the same genetic code but have d
 ifferent structural patterns which correlate with the cell's function (e
 .g. gene expression). This talk will discuss recent research understandi
 ng chromosome structure at the molecular scale\, and its relation to cel
 l function. The talk will present results interpretted from groundbreaki
 ng experiments of the past decade (Hi-C\, and more recently\, single-cel
 l Hi-C)\, which capture information about chromosome structure. While Hi
 -C experiments are useful to identify general rules of chromosome organi
 sation on average\, single-cell Hi-C experiments expose individual varia
 tions. I will show how coarse-grained molecular simulations informed by 
 these experimental data can provide models of chromosome structure cover
 ing the whole genome. Examples will include variations of chromosome str
 ucture throughout the cell cycle\, from cell-division to cell-division\,
  and during the very early stages of embryonic development.
LOCATION:D2.02 Engineering
CATEGORIES:
LAST-MODIFIED:20190121T091926Z
ORGANIZER;CN="":
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