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BEGIN:VEVENT
DTSTAMP:20260413T140432Z
DTSTART;VALUE=DATE-TIME:20190515T130000
DTEND;VALUE=DATE-TIME:20190515T140000
SUMMARY:BMS Seminar by Professor Andrew Carter\, MRC Laboratory of Molecu
 lar Biology\, University of Cambridge
TZID:Europe/London
UID:20190515-8a1785d8699b63720169c3c90f51711e@warwick.ac.uk
CREATED:20190515T074656Z
DESCRIPTION:Abstract: Cell organization and internal movement depends on 
 motor proteins. My lab studies cytoplasmic dynein and its cofactor dynac
 tin. The 2.4MDa dynein/dynactin complex was\, until recently\, the least
  understood of all the cytoskeletal motors. Our interest focuses on how 
 a single dynein carries almost all of the minus-end-directed microtubule
  transport in our cells. It is becoming clear that there is a large fami
 ly of cargo adaptors that contain long coiled coils and can activate dyn
 ein’s long distance movement. We used cryo-electron microscopy (cryoEM) 
 to show how these adaptors recruit dynein to the filament of actin-relat
 ed protein (Arp1) in dynactin. We revealed how formation of this complex
  activates dynein. We also discovered that dynactin can recruit two dyne
 ins side-by-side resulting in a faster moving complex. Our future goal i
 s to understand how the core dynein/dynactin/adaptor complexes are recru
 ited to the many cargos that depend on dynein for their transport
LOCATION:GLT3\, Warwick Medical School
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20190515T074656Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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