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BEGIN:VEVENT
DTSTAMP:20260407T040548Z
DTSTART;VALUE=DATE-TIME:20190621T130000
DTEND;VALUE=DATE-TIME:20190621T140000
SUMMARY:Life Sciences seminar by Prof. Neal Silverman\, University of Mas
 sachusetts Medical School
TZID:Europe/London
UID:20190621-8a1785d86b4b54b3016b5512cd61177c@warwick.ac.uk
CREATED:20190614T082024Z
DESCRIPTION:"Adventures in Innate Immunity from Flies to Mice" The Drosop
 hila innate immune response is rapidly and robustly activated by microbi
 al cell walls\, especially by peptidoglycans from bacteria. The recognit
 ion of peptidoglycan occurs in the extracellular space\, at the cell sur
 face\, and within the cytosol\, depending on the exact chemical nature o
 f the agonist. Cytosolic recognition of peptidoglycan requires a newly c
 haracterized family of conserved transport proteins\, the SLC46 family\,
  that functions in both flies and mice to enable small fragments of pept
 idoglycan to access intracellular compartments where it can be sensed by
  cytosolic innate immune receptors. Regardless of the location\, innate 
 immune recognition of peptidoglycan in Drosophila activates one of two N
 F-kB signaling pathways\, either the Toll or Imd pathways. The Imd pathw
 ay\, in particular\, is activated by DAP-peptidoglycan\, common to gram-
 negative bacteria\, and drives the activation of the NF-kB precursor pro
 tein Relish through a signaling pathway with striking similarity to the 
 TNFR pathway. For signaling through the Imd pathway\, the peptidoglycan 
 receptors PGRP-LC or PGRP-LE and the signaling adapter Imd form function
 al amyloids\, that are required for signaling transduction and are highl
 y regulated.
LOCATION:BSR3\, Gibbet Hill campus
CATEGORIES:Faculty of Science
LAST-MODIFIED:20190614T082024Z
ORGANIZER;CN=Jeanette Morgan:
END:VEVENT
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