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BEGIN:VEVENT
DTSTAMP:20260410T162655Z
DTSTART;VALUE=DATE-TIME:20190620T130000
DTEND;VALUE=DATE-TIME:20190620T140000
SUMMARY:CDB Seminar: Regulation of E-cadherin dynamics during Drosophila 
 development\, Dr Natalia Bulgakova\, Sheffield University
TZID:Europe/London
UID:20190620-8a1785d86b4b54b3016b55c818d7228c@warwick.ac.uk
CREATED:20190618T141917Z
DESCRIPTION:The abstract: E-cadherin cell-cell adhesion is vital for main
 taining the integrity of epithelial tissues. For the lifetime of a tissu
 e\, E-cadherin molecules on the cell surface connect cells to their neig
 hbours by physically binding E-cadherin molecules on these neighbouring 
 cells. However\, despite appearing static\, E-cadherin cell-cell adhesio
 n is highly dynamic and undergoes constant remodelling. The key process 
 in remodelling E-cadherin cell-cell adhesion is recycling\, whereby the 
 protein is internalized from the cell surface within membrane vesicles a
 nd is then transported along an intricate route of intracellular compart
 ments. Following a sorting decision\, it can be recycled back to the cel
 l surface or degraded. The correct progression of each step of this proc
 ess determines the total amount of E-cadherin present at the cell surfac
 e and thus\, adhesion strength. Using Drosophila as a model system our l
 ab is investigating the molecular mechanisms and regulation of E-cadheri
 n trafficking and its role during the development of an organism.
LOCATION:GLT3\, Warwick Medical School
CATEGORIES:BiomedicalSciences,DivisionalSeminars,BMS_CDB
LAST-MODIFIED:20190618T141917Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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