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BEGIN:VEVENT
DTSTAMP:20260407T162011Z
DTSTART;VALUE=DATE-TIME:20201015T123000
DTEND;VALUE=DATE-TIME:20201015T133000
SUMMARY:CSRL Seminar : The Evolutionary Origin of Embryo Implantation and
  the Decidual Cell: implications for the role of inflammation in female 
 reproduction\, Günter P. Wagner\, Yale University
TZID:Europe/London
UID:20201015-8a1785d874f8c8320174fe6332af178f@warwick.ac.uk
CREATED:20201006T154732Z
DESCRIPTION:Abstract: Female reproductive physiology is highly complex no
 t the least because of the necessity of direct interaction and integrati
 on between the fetus and the mother. An example is the role of inflammat
 ory processes\, which seem to be necessary at the beginning of pregnancy
  and a thread for the continuation of pregnancy later in the gestational
  period. Comparative work in the gray short tailed opossum\, Monodelphis
  domestica\, a marsupial with very short period of direct fetal-maternal
  contact in the uterus\, suggests that inflammation was ancestrally pres
 ent because of the effect of embryo attachment on the uterine mucosa. Ne
 ver the less\, the hypothesized ancestral inflammatory reaction was modi
 fied\, both in the marsupial and the placental mammalian lineage. Specif
 ically in Monodelphis\, the inflammation seems to be supported by both t
 he maternal as well as the fetal tissues [cooperative inflammation] and 
 likely plays a role in effecting parturition. In placental mammals the i
 nflammatory reaction evolved to exclude neutrophil infiltration\, and ul
 timately leads to an anti-inflammatory regime at the fetal maternal inte
 rface. We propose that the initial function of the decidual stromal cell
 \, a cell type that only exists in placental mammals\, was to mediate th
 e switch from the inflammatory to the anti-inflammatory phase of embryo 
 implantation. Our results suggest that generic anti-inflammatory treatme
 nt at the beginning of pregnancy (during implantation) might be counterp
 roductive\, but may be compatible with normal physiology if deemed neces
 sary later in pregnancy.
LOCATION:
URL:https://warwick.ac.uk/fac/sci/med/staffintranet/divisions/bms/virtual
 _community
ATTACH:https://warwick.ac.uk/fac/sci/med/staffintranet/divisions/bms/virt
 ual_community
CATEGORIES:BiomedicalSciences,DivisionalSeminars,CSRL
LAST-MODIFIED:20201006T154732Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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