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BEGIN:VEVENT
DTSTAMP:20260403T180604Z
DTSTART;VALUE=DATE-TIME:20210520T123000
DTEND;VALUE=DATE-TIME:20210520T133000
SUMMARY:BMS Divisional Webinar : Dr Douglas Gibson\, Defining the heterog
 eneity and function of macrophages during endometrial tissue repair\, Pr
 incipal Investigator and Sir Henry Dale Fellow\, Centre for Inflammation
  Research\, University of Edinburgh
TZID:Europe/London
UID:20210520-8a1785d878f9810801796b016fee032b@warwick.ac.uk
CREATED:20210514T131206Z
DESCRIPTION:Abstract: Endometrial repair is essential for women’s reprodu
 ctive health and ongoing fertility. Macrophages are essential mediators 
 of tissue repair\, but we lack fundamental knowledge about how they are 
 regulated in the endometrium. Although there is consensus that macrophag
 es are necessary for repair\, their nature\, origins\, and the environme
 ntal factors that control their behaviour remain poorly understood there
 by limiting our understanding of their function in the endometrium in he
 alth and disease. We have used Csf1r-eGFP transgenic reporter mice in wh
 ich cells of the monocyte/macrophage lineage are labelled with eGFP (Mac
 Green) to characterise macrophages during endometrial repair. We have sh
 own that CSF1R+ cells are abundant during endometrial repair and found t
 hat monocyte and macrophage subpopulations associate with spatially dist
 inct regions of tissue breakdown and repair ([1]). We performed multipar
 ameter flow cytometry on uterine repair tissues using established subset
  markers for monocytes and mature macrophages and found that theses popu
 lations change dynamically during repair with considerable evidence for 
 heterogeneity within the endometrial macrophage compartment. To investig
 ate this further we performed unbiased profiling of CD45+ cells using si
 ngle cell RNA sequencing which confirmed the presence of multiple monocy
 te/macrophage subtypes with potentially distinct ontogenies. Further ana
 lysis across distinct time points during endometrial breakdown (12hr)\, 
 repair (24hr) and remodelling (48hr) identified that endometrial repair 
 was associated with extensive monocyte infiltration during active repair
  but that mature macrophages were predominant during endometrial remodel
 ling following resolution of inflammation. These studies offer new insig
 hts into the regulation of the endometrial macrophage compartment during
  endometrial repair and provide a platform for understanding how the phe
 notype and function of these cells could be dysregulated in women’s repr
 oductive health disorders. [1] Cousins\, F.L.\, Kirkwood\, P.M.\, Saunde
 rs\, P.T.K. & Gibson D.A. Evidence for a dynamic role for mononuclear ph
 agocytes during endometrial repair and remodelling. Sci Rep 6\, 36748 (2
 016). https://doi.org/10.1038/srep36748 Biography: Dr Douglas Gibson is 
 a Principal Investigator & Sir Henry Dale Fellow in the Centre for Infla
 mmation Research at the University of Edinburgh. His research focuses on
  understanding how hormones control immune cell function in the womb and
  how this might affect women's reproductive health. His lab uses fate-ma
 pping techniques\, transcriptomics analysis\, multiparameter flow cytome
 try and immunohistochemistry in order to characterise the phenotype and 
 function of immune cell populations that are required for endometrial re
 pair and remodelling. He is the recipient of the Wellcome-Beit Prize\, S
 ociety for Reproduction and Fertility New Investigator Award and the Soc
 iety for Endocrinology Early Career Prize lecture.
LOCATION:
CATEGORIES:BiomedicalSciences,DivisionalSeminars,BMS_TEM,CSRL
LAST-MODIFIED:20210514T131206Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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