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BEGIN:VEVENT
DTSTAMP:20260404T193910Z
DTSTART;VALUE=DATE-TIME:20220610T140000
DTEND;VALUE=DATE-TIME:20220610T150000
SUMMARY:Life Sciences seminar by Prof. Elizabeth Robertson FRS
TZID:Europe/London
UID:20220610-8a1785d880f5871701811a10f4de747a@warwick.ac.uk
CREATED:20220531T122207Z
DESCRIPTION:Signaling pathways regulating cell fate allocation in the ear
 ly mouse embryo Shortly after implantation mouse embryo comprises of thr
 ee distinct epithelial layers. The founder tissue of the embryo proper\,
  the epiblast\, forms a radially symmetrical cup of cells that grows in 
 close apposition to the extra-embryonic ectoderm and visceral endoderm t
 o form a simple cylindrical structure. Reciprocal inductive interactions
  between these tissues\, mediated by the activity of the TGFb growth fac
 tor Nodal expressed in the epiblast\, are responsible for establishing i
 nitial axis polarity of the embryo. Some hours later\, during gastrulati
 on\, dose-dependent Nodal activities regulate the process of cell fate a
 llocation to generate the early body plan. We have identified the T-box 
 transcription factor Eomesodermin (Eomes) as a key Nodal target gene tha
 t plays multiple roles in the early embryo in specification of discrete 
 cellular sub-sets and progenitor populations. I will focus on our curren
 t understanding as to how dynamic Eomes expression executes cell type sp
 ecific roles\, with a particular focus on our recent findings for Eomes 
 requirements for the first waves of embryonic blood formation.
LOCATION:GLT2
URL:
ATTACH:
CATEGORIES:Faculty of Science
LAST-MODIFIED:20220531T122207Z
ORGANIZER;CN=Jeanette Morgan:
END:VEVENT
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