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BEGIN:VEVENT
DTSTAMP:20260408T160545Z
DTSTART;VALUE=DATE-TIME:20240626T130000
DTEND;VALUE=DATE-TIME:20240626T140000
SUMMARY:BMS Seminar: Dynamics and mechanics of epithelial cells in 2D and
  3D\, Professor Andreas Janshoff\, Institute of Physical Chemistry\, Uni
 versity of Göttingen
TZID:Europe/London
UID:20240626-8a1785d88e515411018e669705060ca6@warwick.ac.uk
CREATED:20240322T143557Z
DESCRIPTION:Abstract: We performed experiments involving indentation-retr
 action/relaxation to observe the viscoelastic properties of epithelial c
 ells undergoing shape alterations. MDCK II cells cultured on flexible po
 lydimethylsiloxane substrates underwent lateral stretching\, resulting i
 n increased cortex contractility and reduced excess surface area. Conseq
 uently\, cells maintained their fluidity but became inherently stiffer. 
 This behavior was consistent across demixed cell monolayers of ZO-1/2 do
 uble knockdown (dKD) cells\, cells exposed to varying temperatures\, and
  following cholesterol removal from the plasma membrane. Conversely\, in
 dividually tested cells adhered to differently sized patches showed no s
 ignificant rheological changes. By sacrificing excess surface area\, cel
 ls gained the ability to respond to mechanical challenges without compro
 mising their fluidity\, thus acquiring newfound flexibility that elucida
 tes the fluidity-stiffness relationship. MDCK cells also form multicellu
 lar cysts like acini or spheroids\, comprised of a closed polarized cell
  monolayer enclosing a liquid. Tissue tension of these cysts is typicall
 y determined using Laplace's law by measuring internal pressure. We cond
 ucted force-relaxation experiments on MDCK II cysts and developed a theo
 retical framework to explain their response to external deformation\, co
 nsidering the potential super-viscoelasticity of the spheroids and volum
 e leakage. Our findings showed that cells reduce tension upon deformatio
 n by thinning the cell monolayer\, thus providing excess tissue area. Th
 is mechanism\, which also protects individual cells from lysis\, serves 
 as a universal strategy on larger scales to withstand external stress. M
 ost human body organs consist of epithelial sheets\, which are layers of
  cells exhibiting intricate and dynamic behaviors not observable in indi
 vidual cells and challenging to predict by studying isolated cells. In t
 his study\, we investigate how the dynamics of cell sheets change concer
 ning the integrity of cell-cell junctions\, particularly focusing on cel
 l-cell junctions and single cell contractility. Biography: 1987-1989 Stu
 dies of Biology at the University of Münster 1989-1994 Studies of Chemis
 try at the University of Münster\, with honor 1994-1997 PhD thesis under
  supervision of Prof. Dr. H.-J. Galla 1997-1998 Postdoctoral Researcher 
 at the Scripps Research Institute (La Jolla\, CA\, USA) 1999-2001 Habili
 tation in Biochemistry at the University of Münster in the group of Prof
 . Dr. H.-J. Galla and Prof. Dr. H. Fuchs 2001-2006 Associate Professor (
 C3) for Physical Chemistry at the University of Mainz 2006-2008 Full Pro
 fessor (W3) for Biophysical Chemistry at the University of Mainz since 2
 008 Full Professor (W3) for Biophysical Chemistry at the University of G
 öttingen 2011-2018 Vice-Speaker CRC 937 2013 - 2015 Dean of the Faculty 
 of Chemistry in Göttingen 2022 – Director of the Institute of Physical C
 hemistry in Göttingen 2022- Vice Speaker RTG CYTA
LOCATION:MTC Lecture Theatre
CATEGORIES:BiomedicalSciences,DivisionalSeminars
LAST-MODIFIED:20240322T143557Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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