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BEGIN:VEVENT
DTSTAMP:20260414T145728Z
DTSTART;VALUE=DATE-TIME:20241120T131500
DTEND;VALUE=DATE-TIME:20241120T141500
SUMMARY:BMS Seminar: Professor Tarvinder Dhanjal and Dr Alexiane Decout\,
  Biomedical Sciences Directorate\, WMS
TZID:Europe/London
UID:20241120-8ac672c492b40dc80192c2a85c204af3@warwick.ac.uk
CREATED:20241030T111222Z
DESCRIPTION:Professor Tarvinder Dhanjal - Diamonds Funding Heart Rhythm R
 esearch Dr Alexiane Decout - Lactobacillus Crispatus Surface Layer Prote
 ins\, Multifaceted Players of Women’s Health Abstract: Preterm birth is 
 the leading cause of death among children under the age of 5yrs. In 30% 
 of cases\, it is preceded by preterm prelabour rupture of the fetal memb
 rane (PPROM). A risk indicator for PPROM is vaginal dysbiosis. Term preg
 nancy is associated with an optimal vaginal microbiota characterised by 
 low diversity\, with lactobacilli species constituting the vast majority
  of the bacteria therein. Conversely\, a switch toward a more diverse mi
 crobiota containing opportunistic pathogenic species and a reduced propo
 rtion of lactobacilli is associated with increased risk of preterm birth
 . Inflammatory pathway activation associated with PPROM can be triggered
  by pro inflammatory stimuli such as TLR4 ligands. Yet\, how the vaginal
  microbiota modulate the fetal immunological environment and thus PPROM 
 risk is not fully understood. Using clinical isolates of vaginal pathoge
 ns and commensals we identified that lactobacilli associated with term b
 irth selectively interacted with anti-inflammatory innate immune recepto
 rs. A unique feature of lactobacilli surfaces is the presence of surface
  layer proteins (SLPs) forming a crystallin array. Removal of SLPs from 
 the surface of L. crispatus restored a strong TLR2 activation\, indicati
 ng that TLR2 ligands are present on L. crispatus\, but are shielded by t
 he S-layer proteins. These S-layer proteins interacted selectively with 
 anti-inflammatory receptors such as DC-SIGN\, were detected in the vagin
 al cervico-vaginal fluids and were associated with decreased maternal in
 flammation in L. crispatus dominated clinical samples. These data provid
 e new insight into immunological mechanisms of microbial associated pret
 erm birth and may offer new targets for novel preventive strategies.
LOCATION:IBRB Lecture Theatre
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20241030T111222Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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