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BEGIN:VEVENT
DTSTAMP:20260726T084411Z
DTSTART;VALUE=DATE-TIME:20260715T131500
DTEND;VALUE=DATE-TIME:20260715T141500
SUMMARY:BMS Seminar: A dopaminergic system - in sickness and in health\, 
 Professor Scott Waddell\, Department of Physiology\, Anatomy and Genetic
 s\, University of Oxford
TZID:Europe/London
UID:20260715-8ac672c49a915c0d019aa11607ba1f5b@warwick.ac.uk
CREATED:20260715T071916Z
DESCRIPTION:Abstract: Memory and motivation provide life with direction a
 nd purpose. Our studies using Drosophila have discovered that functional
  heterogeneity of the dopaminergic system is an organising principle of 
 mnemonic networks. Identifiable parallel combinations of dopaminergic ne
 urons reinforce valence and reward-specific memories. In addition\, oppo
 nency in the system provides need-dependent control of memory expression
 \, and update functions when learned expectations are not met. Overridin
 g the system’s inherent reward-specificity produces inappropriate compul
 sive reward-seeking. I will discuss a recent study of malaise learning t
 hat informs of general mechanisms of memory\, adds new functionality to 
 the dopaminergic system\, and may provide a novel inroad to understandin
 g its vulnerability. Biography: Scott Waddell is Professor of Neurobiolo
 gy in the Centre for Neural Circuits and Behaviour in the Department of 
 Physiology\, Anatomy and Genetics at the University of Oxford. He is cur
 rently Deputy Head of Department. Scott studies molecular\, cellular and
  neural circuit mechanisms of memory and motivation using genetic approa
 ches in Drosophila. His work has revealed extensive heterogeneity in the
  structure and function of the dopaminergic system. His group found that
  different populations of dopaminergic neurons represent specific types 
 of reward. They also demonstrated that opposing dopaminergic systems pro
 vide motivational control and update memories when learned expectations 
 are unmet. Together his studies indicate that informed behaviour arises 
 from a catalogue of parallel memories. Scott read biochemistry in Dundee
  and obtained his PhD in cancer biology in London. He shifted field and 
 continent for a postdoc at Massachusetts Institute of Technology. After 
 10 years as a group leader at UMass Medical School\, he relocated to Oxf
 ord as a Wellcome Senior and then Principal Research Fellow. Scott is Fe
 llow of the Royal Society\, a Fellow of the Academy of Medical Sciences\
 , a member of EMBO\, and was awarded the 2014 Liliane Bettencourt Prize 
 for Life Sciences.
LOCATION:A151(MBU)\, Medical School Building
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20260715T071916Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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