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BEGIN:VEVENT
DTSTAMP:20260407T064516Z
DTSTART;VALUE=DATE-TIME:20251008T131500
DTEND;VALUE=DATE-TIME:20251008T141500
SUMMARY:BMS Seminar: Laboratory evolution unravels a novel feedback syste
 m on Cdk function\, Dr Damien Coudreuse\, Institute of Biochemistry and 
 Cellular Genetics
TZID:Europe/London
UID:20251008-8ac672c69956c0cd019957ea4f690ce7@warwick.ac.uk
CREATED:20250917T134317Z
DESCRIPTION:Abstract: The proliferation of eukaryotic cells is regulated 
 by a complex and intricate network of regulatory systems that promotes e
 fficient progression through the cell cycle and ensures the adequate res
 ponse of cells to their environment. Despite this complexity\, evidence 
 suggests that the core inputs that are necessary and sufficient to allow
  for proper alternation of DNA replication and mitosis are surprisingly 
 simpler than anticipated. Thus\, in the fission yeast S. pombe\, cells o
 perating with a minimal cell cycle network (MCN) that lacks a number of 
 elements of the endogenous circuit are virtually identical to wild type.
  In this background\, even the conserved Wee1+Cdc25 feedback loops are d
 ispensable (MCN-AF cells)\, although their loss impact population growth
 . To explore the mechanisms that allow for cells with a basic cell cycle
  network to evolve and improve their proliferation\, we took advantage o
 f laboratory evolution assays\, using the fission yeast MCN-AF backgroun
 d as a starting point. This allowed us to identify a new feedback contro
 l on Cdk function mediated by the small disordered protein Spo12 and ope
 rating at both mitotic entry and exit. We show that Spo12 defines a new 
 and conserved family of stoichiometric inhibitors of the Cdk-counteracti
 ng PP2A\, which are directly regulated by Cdk-dependent phosphorylation.
  Altogether\, our study provides new insight into the regulation of cell
  cycle progression and how simplification of the cell circuit can promot
 e population growth. Biography: Damien Coudreuse pursued his PhD in the 
 team of Dr Hendrik Korswagen at the Hubrecht Institute\, Holland\, study
 ing the regulation of the Wnt signaling pathway and its role in cell mig
 ration in the nematode C. elegans. For his post-doctoral work\, he joine
 d the group of Dr. Paul Nurse at the Rockefeller University\, USA\, and 
 focused on deciphering the principles and core inputs of the division cy
 cle in fission yeast. He established his own research team at the Instit
 ute of Genetics and Development of Rennes\, France\, in 2012\, where he 
 pursued his studies on cell cycle progression in S. pombe while developi
 ng state-of-the-art technologies and new lines of research. Since 2022\,
  his lab moved to the Institute of Biochemistry and Cellular Genetics in
  Bordeaux\, France. Combining fission yeast genetics\, live-cell imaging
 \, microfluidics\, evolutionary approaches and biophysical methods\, his
  current work explores a broad range of questions\, and in particular ho
 w cells can evolve to improve their growth\, how cell size and evolution
  are linked and the interplay between intracellular crowding and aging.
LOCATION:IBRB Lecture Theatre\, Gibbet Hill Campus
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20250917T134317Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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