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BEGIN:VEVENT
DTSTAMP:20261016T080010Z
DTSTART;VALUE=DATE-TIME:20261111T131500
DTEND;VALUE=DATE-TIME:20261111T141500
SUMMARY:BMS Seminar: Senescence: Elimination or Escape as a Step to Cance
 r\, Dr Kirsten Sadler Edepli\, New York University Abu Dhabi
TZID:Europe/London
UID:20261111-8ac672c7a133392901a13974c71545c1@warwick.ac.uk
CREATED:20261014T080836Z
DESCRIPTION:Abstract: Cellular senescence is a complex state that can eit
 her suppress or promote cancer. Because senescence is frequently accompa
 nied by epigenetic changes\, we used a zebrafish model of early-stage li
 ver cancer driven by overexpression of the epigenetic regulator UHRF1 to
  investigate how epigenome reprogramming generates distinct senescent ce
 ll states and influences cancer development. Functional studies revealed
  that cells with different senescence signatures and levels of UHRF1 hav
 e distinct cancer-related properties and vulnerabilities. Cells expressi
 ng lower levels of UHRF1 can re-enter the cell cycle following loss of t
 p53 whereas cells with high UHRF1 levels remain arrested and are selecti
 vely targeted by the senolytic drug Navitoclax. These findings demonstra
 te how epigenetic differences can determine the fate of senescent cells 
 and may provide a mechanistic basis for patient stratification and the d
 evelopment of more targeted cancer therapies. Biography: Dr. Kirsten Sad
 ler (Edepli) is a geneticist and cell biologist whose research explores 
 how epigenetic mechanisms regulate development\, regeneration\, and dise
 ase. She earned a Master’s in Medicine from Harvard Medical School\, a P
 h.D. from Harvard University\, and completed postdoctoral training at MI
 T\, where she used zebrafish to identify genes essential for liver devel
 opment and disease. Her current work focuses on epigenetics in liver dev
 elopment\, regeneration\, cancer\, and transposon regulation in zebrafis
 h\, mice\, and octopus\, defining how the epigenetic changes caused by o
 ncogenic stimuli and aging deregulate cell proliferation\, impair liver 
 function\, and block regeneration. A pioneer in using zebrafish to model
  liver disease and toxicant-induced injury\, Dr. Sadler has published ov
 er 75 scientific papers and secured significant research funding from US
  and international funding. In addition to her research accomplishments\
 , she is a committed mentor and advocate for equity in science and has h
 eld senior leadership roles at NYU Abu Dhabi focused on faculty developm
 ent\, inclusion\, and advancement. Dr. Sadler is a tenured Professor of 
 Biology at NYU Abu Dhabi and a Global Network Professor at NYU. She and 
 her husband have 4 children and live in Abu Dhabi.
LOCATION:GLT3\, Medical School Building
URL:
ATTACH:
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20261014T080836Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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