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BEGIN:VEVENT
DTSTAMP:20260907T223204Z
DTSTART;VALUE=DATE-TIME:20210118T130000
DTEND;VALUE=DATE-TIME:20210118T140000
SUMMARY:WCPM: Timothy Saunders (Warwick)
TZID:Europe/London
UID:20210118-8a1785d778f97ee601797ee5061a530a@warwick.ac.uk
CREATED:20210518T095329Z
DESCRIPTION:WCPM: Timothy Saunders (Warwick) 1pm - 2pm\, Mon\, 18 Jan '21
  To join click here. Stochastic activation and bistability in a biologic
 al regulatory network Rab GTPases are the central regulators of intracel
 lular traffic. Their function relies on their conformational change trig
 gered by nucleotide exchange and hydrolysis. While this switch is well u
 nderstood for an individual protein\, how Rab GTPases collectively trans
 ition between different states is not known. Here\, we combine in vitro 
 reconstitution experiments with stochastic modelling to study the non-eq
 uilibrium properties of the minimal Rab5 activation network. We find tha
 t collective switching of Rab5 relies on a positive feedback and is trig
 gered by intrinsic noise due to low amounts of Rab5[GDP] preexisting on 
 the membrane. We show that this inactive population is not only the sour
 ce of stochastic behavior of this biochemical circuit\, but can act as a
  control parameter for Rab5 activation. We also discuss future direction
 s regarding the effects of spatial constraints on stochastic switches in
  biological systems.
LOCATION:
CATEGORIES:WCPM
LAST-MODIFIED:20210518T095329Z
ORGANIZER;CN=Emma Mosley:
END:VEVENT
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