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Science City Research Alliance

Advanced Materials 2 Mass Spectrometry

Bruker MaXis with Proxeon Easy-nLC and Dionex RS3000 HPLC
Location Chemistry, University of Warwick (C115a)
Custodian Dr Lijiang Song and Professor Peter Sadler
Applications

Ultra high resolution – time of flight mass spectrometer (TOF-MS) for use in applications such as: identification of small molecules, metabolomics

quantitative proteomics, biomarker discovery,

characterisation of (bio)polymers and supramolecular assemblies
Specification
  • Resolution > 40,000 FWHM
  • MS and MS/MS mass accuracy typically between 600 – 800 ppb
  • Acquisition rate up to 20 Hz
AM2 MaXis

Bruker HCT-Ultra, ETD Discovery
Location Chemistry, University of Warwick (B121)
Custodian Dr Lijiang Song and Professor Peter Sadler
Applications

High capacity ion traps

Identification of small molecules, metabolomics, quantitative proteomics, biomarker discovery,

characterisation of (bio)polymers and supramolecular assemblies
Specification
  • CID/ETD
  • MSn
  • LC-MS/MSn
AM2 HCT

KORE Surface Seer
Location Chemistry, University of Birmingham
Custodian Professor Jon Preece
Applications The Surface Seer is a time-of-flight SIMS instrument dedicated to investigating the surface chemistry of materials. A focused caesium
ion beam scans an area typically 500 x 500 μm on the surface of a sample. This results in mass spectra characteristic of the very
top-most atom layers of the sample, which is of increasing importance in materials engineering, biomaterials, drug delivery, etc.
The instrument detects all elements of the periodic table from hydrogen to uranium down to ppm levels, but its real strength is the ability to provide unique information about organic compounds on surfaces, even coatings or structures just a few atom layers thick. Various surface phenomena, such as self-assembled monolayers, can be characterised.
Specification
  • Reflectron energy analyser
  • Positive and negative ion modes
  • Analysis of both insulating and conducting samples
  • Mass range >1000 m/z
  • Mass accuracy of ± 10 mamu
  • Samples must be vacuum-compatible
KORE

Waters Micro MX MALDI Mass Spectrometer
Location Chemistry, University of Birmingham (floor 1)
Custodian Peter Ashton
Applications High-performance, matrix-assisted laser desorption/ionisation time-of-flight mass spectrometer featuring parallel position sensitive detection (PSD) technology for confirming protein identification and determining posttranslational modifications.
Negative ion capability allows applications in genotyping and polysaccharide analysis.
Specification
  • Enables analysis of sub-femtomole quantities of biological and synthetic molecules
  • Molecular weight range 200 Da - >500 KDa
  • High resolution spectra obtained with m/z <4kDa in reflection mode
MALDI

Waters GCT Premier GC-MS
Location Chemistry, University of Birmingham (floor 1)
Custodian Peter Ashton
Applications An orthogonal acceleration time-of-flight mass spectrometer with high resolution for the selectivity needed to separate analyte spectra from isobaric interferences and background chemical noise. Identifies the elemental compositions of small molecules.
Specification
  • Sub-5 ppm RMS
  • EI, CI and FI ionisation
GCMS