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Accelerate CHNUK AMR Discovery

Overview

Accelerate CHNUK is a £1M programme jointly funded by Research Councils UK and the National Natural Sciences Foundation of China. (View UK-China AMR Partnership Initiative Funding Call)

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Accelerate CHNUK aims to find solutions to Antimicrobial Resistance using Biochemistry, Chemistry, Genetics, Physiology and Structural Biology.

Together, with an exceptional scientific advisory panel and an unprecedented breadth of committment from pharma experts and industry, this highly interactive environment is expected to maximise future translational development.

Combining Expertise

Accelerate CHNUK researchers combine in-depth knowledge in bacterial cell wall metabolism, RNA Polymerase research and novel bacterial targets.

UK teams: Warwick, Oxford, Diamond Light Source Harwell, Imperial College, Dundee, Sheffield and Newcastle

China teams: Chinese Academy of Sciences, Materia Medica and Shanghai Synchotron

Fragment Based Lead Discovery

Accelerate CHNUK integrates novel high throughput structural approaches to deliver new chemical probes, which will reveal mechanistic insights, validate novel targets and chemistry leads for industry partners to more effectively target bacterial enzymes.

Delivering an enduring innovative China-UK AMR solution:

1.Establish a high-tech trans-national training environment for the next generation of researchers in China and UK

2.Enable fragment based lead discovery (FBLD) technology transfer between Diamond and Shanghai synchrotrons to accelerate antibiotic discovery in China

3.Add FBLD technology for biological probes and inhibitors to high profile AMR funded projects in China and UK

4.Establish knowledge and technology transfer across China and UK research groups

5.Accelerate validation of novel targets and discovery of inhibitors

 

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In the UK, the work is led by the University of Warwick (Prof Chris Dowson), alongside Oxford, Diamond Light Source, Imperial College London, Dundee, Sheffield and Newcastle.

In China, Prof Yang leads teams at the Chinese Academy of Sciences, Materia Medica and the Shanghai Synchrotron.