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Souvik Naskar

I am currently a second year PhD student (Roper group, Structural Biology, University of Warwick), studying Interdisciplinary Biomedical Research (IBR) as part of the 4-years Integrated MSc and PhD (1+3) programme funded by Medical Research Council - Doctoral Training Partnership (MRC-DTP). My current project is based on high resolution single molecule in-vitro and in-vivo imaging of a bacterial cell divisome protein complex, using cryo-electron microscopy and light microscopy, respectively. The organisation of the divisome protein complexes involved in bacterial cell division has massive scientific impact in terms of exploring principles and architecture to eukaryotic cell division through evolutionary relationships, furthermore in exploiting the essential protein-protein interactions in quest for next generation antimicrobial development. The ultimate goal of this current project is to deduce the structure of a divisome protein compex that could be a potential novel target for next generation of antibiotics. The project involves aspects of antimicrobial resistance (AMR), cellular dynamics and infection, which are among MRC's strategic skill priorities. Moreover, AMR is under a global action plan (.pdf) adopted by world health organisation (WHO) in 2015.

During my early career at the University of Sussex, I had been involved in various research projects where I developed my technical skills working in different labs and interests in the research field. In 2009, I started working with Prof. George Kemenes on an MRC-funded project in the field of learning and memory, developed my behavioural pharmacology skills, biochemical assays, several quantification methods and successfully published two articles (Wan et al., 2010; Korneev et al. 2015). I received a Wellcome Trust Value in Person (VIP) award to continue an independent research and published my first authorship article (Naskar et al., 2014) in Nature Communication. Simultaneously, I continued working with my MSc project supervisor Prof. Guy P. Richardson on part-time basis on a Wellcome Trust funded 'Cellular and molecular basis of hearing' where I developed my molecular biology and protein chemistry skills, investigating tectorial membrane proteins and their interactions during several developmental stages (Cheatham et al., 2014). Since 2010 until joining the University of Warwick in 2015, I had been on successive BBSRC grants on multi-disciplinary neuroscience projects, where working with Dr. Ildiko Kemenes, I successfully contributed to two articles (Pirzer et al. 2014a and 2014b ). While working on these projects, I built up a strong technical background in cellular and molecular neuroscience, a good experience of conducting research and confidence of working independently with minimum supervision.

EDUCATION:
  • 2016 - Present: MRC-DTP funded PhD in Interdisciplinary Biomedical Research (IBR); University of Warwick, UK.
  • 2015 - 2016: MRC-DTP funded MSc in IBR (Distinction); University of Warwick, UK.
  • 2006 - 2007: MSc in Genetic Manipulation and Molecular Cell Biology (GMMCB), University of Sussex, UK.
  • 2001- 2005: B. Tech in Biotechnology, West Bengal University of Technology, India.
ACADEMIC HONORS AND AWARDS:
  • Flexible Training Award (MRC), University of Warwick, UK, Jan 2017
  • MRC-DTP PhD Studentship (Full), University of Warwick, UK, 2015 – 2019
  • Wellcome Trust VIP Award for ‘Research Assistantship’; University of Sussex, UK, Aug-Sept 2009
  • Overseas Student Scholarship (Partial) for MSc Study; University of Sussex, UK, 2006
  • Shilpa Visharad (An honour in excellence of Fine Arts & Painting); Sarbabharatiya Sangeet-O-Sanskriti Parishad (SSOSP), West Bengal State Academy of Fine Arts, Kolkata, India, 2001
PUBLICATIONS:

1. Korneev, SA., Maconochie, M., Naskar, S., Korneeva, EI., Richardson, GP., O’Shea, M. (2015) A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression. Scientific Report, 5:11815. DOI: 10.1038/srep11815.

2. Naskar, S., Wan, H. and Kemenes, G. (2014) pT305-CaMKII stabilizes a learning-induced increase in AMPA receptors for ongoing memory consolidation after classical conditioning. Nature Communications, 5: 3967. DOI: 10.1038/ncomms4967; recommended by F1000Prime.

3. Pirger, Z., Crossley, M., László, Z., Naskar, S., Kemenes, G., O’Shea, M., Benjamin, PR., Kemenes, I (2014b) Interneuronal Mechanism for Tinbergen’s Hierarchical Model of Behavioral Choice. Current Biology, Volume 24, Issue 17, p2018–2024, DOI: http://dx.doi.org/10.1016/j.cub.2014.07.044

4. Cheatham, MA., Goodyear, RJ., Homma, K., Legan, PK., Korchagina, J., Naskar, S., Siegel, JH., Dallos, P., Zheng, J and Richardson, GP (2014) Loss of the Tectorial Membrane Protein, CEACAM16, Enhances Spontaneous, Stimulus-frequency and Transiently-evoked Otoacoustic Emissions. Journal of Neuroscience, 34(31): 10325-10338; DOI: 10.1523/JNEUROSCI.1256-14.2014

5. Pirger, Z., Naskar, S., László, Z., Kemenes, G., Reglodi, D., and Kemenes, I (2014a) Reversal of Age-Related Learning Deficiency by the Vertebrate PACAP and IGF-1 in a Novel Invertebrate Model of Aging: The Pond Snail (Lymnaea stagnalis). Journal of Gerontology: Series A Biological Science Medical Science, DOI: 10.1093/gerona/glu068

6. Wan, H., Mackay, B., Iqbal, H., Naskar, S. and Kemenes, G (2010) Delayed intrinsic activation of an NMDA-independent CaM-kinase II in a critical time window is necessary for late consolidation of an associative memory. Journal of Neuroscience, 30(1):56-63. doi: 10.1523/JNEUROSCI.2577-09.2010.

 

 

Souvik Naskar

MRC-DTP funded PhD Student
Interdisciplinary Biomedical Research
Warwick Medical School

Supervisors & Lab:

Prof. David Roper (Roper group)
Prof. Corinne Smith (Smith Lab)
C10, Structural Biology
School of Life Science
University of Warwick
Coventry CV4 7AL, UK

E-mail: S.Naskar.1@warwick.ac.uk