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Information for the public

What is the Alife2 study?

Alife2 is a study investigating whether anti-coagulant (blood-thinning) treatment reduces the risk of miscarriage in women with two or more (unexplained) miscarriages and inherited thrombophilia- a blood-clotting problem.

If you might be interested in taking part in the Alife2 trial, here’s what you need to know:

Who can take part?

You may be able to take part in the trial if a blood test shows that you have inherited thrombophilia and:

  • You have had two or more miscarriages
  • You are aged between 18 and 42
  • You are trying for a baby, or plan to try, and are not yet pregnant and
  • You are willing to be ‘randomised’ – to be chosen at random – to either the trial treatment or standard care.

What would I need to do?

Participants randomised to trial treatment will be instructed in how to inject themselves once daily with a dose of anti-coagulant in either upper leg or abdomen. Treatment would start at or within 7 weeks of a confirmed pregnancy (based on first day of the last period) and continue until the start of labour or the end of the pregnancy.

Participants who are randomised to standard care won't need to inject themselves at all, but will be given the normal pregnancy care, although they will be followed up by the research team.

Where is it taking place?

The following hospitals are currently recruiting patients:

England

  • Basingstoke: Basingstoke and North Hampshire Hospital
  • Birmingham: Heartlands Hospital
  • Birmingham: Birmingham Women's Hospital
  • Bolton: Royal Bolton Hospital
  • Cambridge: Addenbrooke’s Hospital
  • Chester: Countess of Chester Hospital
  • Chesterfield: Chesterfield Royal Hospital
  • Coventry: University Hospital Coventry
  • Cumbria: University Hospitals of Morecambe Bay
  • Harrogate: Harrogate District Hospital
  • Kingston Upon Thames: Kingston Hospital
  • Leicester: Leicester Royal Infirmary
  • Leeds: St James University Hospital
  • Liverpool: Liverpool Women’s Hospital
  • London: Epsom and St Helier University Hosptials NHS Trust
  • London: North Middlesex University Hospital
  • London: Royal Free Hospital
  • London: University College London Hospital (UCLH)
  • London: University Hospital Lewisham
  • Manchester: St Mary’s Hospital
  • Manchester: Stepping Hill Hospital
  • Nottingham: Queens Medical Centre
  • Oxford: John Radcliffe Hospital
  • Sheffield: Jessop Wing (Royal Hallamshire Hospital)
  • Southampton: University Hospital Southampton
  • Tameside and Glossop: Tameside General Hospital
  • Wirral: Arrowe Park Hospital

Northern Ireland

  • Belfast: Ulster Hospital

Scotland

  • Ayrshire and Arran: University Hospital Crosshouse

Wales

  • Swansea: Singleton Hospital

Please ring 02476 964 983 to speak to the Clinic Secretary about your interest in this research. Your eligibility for the study will be assessed and if you are eligible you will be given further information about how to take part.

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Enquiries:

 Tel: 02476 150589
Email: alife2@warwick.ac.uk