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Recurrent miscarriage (two or more miscarriages in a row) causes considerable distress for women and their partners. The vast-majority of couples receive supportive care only, as few treatments have been shown to prevent miscarriage. The hope is that this trial may help those who currently have no explanation for the reason they have experienced recurrent miscarriage.
Information about the trial
|What is the purpose of the research trial?|
The aim of the CERM trial is to find out if antibiotics can reduce miscarriage.
In some women the lining of the womb (the endometrium) is inflamed (a condition called endometritis). Researchers have found a link between this and miscarriage. A healthy endometrium is important for the embryo to be able to attach to the womb.
Treating endometritis with antibiotics may reduce the inflammation and the likelihood of a miscarriage. This research trial will test this theory by comparing a 14-day course of an antibiotic (doxycycline) against a placebo to find out if taking antibiotics reduces miscarriages.
|What does the trial involve?|
Whether you will receive doxycycline or the placebo is decided by chance.
|Where is the trial taking place?|
The CERM trial is currently running at the following locations:
How can I be referred to take part?
You may be able to take part in the CERM trial if:
Please ask your GP to refer you, via the NHS choose and book system, to Professor Siobhan Quenby at the recurrent miscarriage clinic at: University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX
|Below is a diagram showing an overview of the CERM trial:|
Please note: 'CERM B' activities only relate to participants at University Hospital Coventry & Warwickshire (who have consented to CERM B)
Email: cerm at warwick dot ac dot uk
Warwick Clinical Trials Unit
Warwick Medical School
University of Warwick
Gibbet Hill Road