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Information for patients

If you have experienced pregnancy loss and would like help or advice please click here for resources.

Recurrent miscarriage (two or more miscarriages in a row) causes considerable distress for women and their partners. The vast-majority of couples receive supportive care only, as few treatments have been shown to prevent miscarriage. The hope is that this trial may help those who currently have no explanation for the reason they have experienced recurrent miscarriage.

Information about the trial

What is the purpose of the research trial?

The aim of the CERM trial is to find out if antibiotics can reduce miscarriage.

In some women the lining of the womb (the endometrium) is inflamed (a condition called endometritis). Researchers have found a link between this and miscarriage. A healthy endometrium is important for the embryo to be able to attach to the womb.

Treating endometritis with antibiotics may reduce the inflammation and the likelihood of a miscarriage. This research trial will test this theory by comparing a 14-day course of an antibiotic (doxycycline) against a placebo to find out if taking antibiotics reduces miscarriages.

What does the trial involve?
  • The taking of an endometrial biopsy (a small sample of tissue from your endometrium) to find out if you have endometritis.
  • If endometritis is present in the tissue examined, you will then be eligible to be randomised to either:
    • 14-day course of an antibiotic (doxycycline) or
    • 14-day course of a placebo (a ‘dummy treatment’ which will look exactly the same as the antibiotic but contains no active ingredients). This is necessary to find out if taking antibiotics reduces miscarriages.

Whether you will receive doxycycline or the placebo is decided by chance.

  • Agreeing to use condoms for 3 months (before biopsy, awaiting results and whilst taking the medication)
Where is the trial taking place?

    The CERM trial is currently running at the following locations:

    • Aberdeen - Aberdeen Maternity Hospital.
    • Bath - Royal United Hospital.

    Contact email: Tel: 01225 821890

    • Birmingham -
    • Bridgend - Princess of Wales Hospital.
    • Burnley - Burnley General Hospital.

    Contact email: Tel: 01282 803081 Extension 13081

    • Cambridge - Addenbrookes Hospital

     Contact email: Tel: 01223 274228

    • Coventry - University Hospital Coventry & Warwickshire
      Contact email: Tel: 02476 964 982
    • Darlington and Durham - Darlington Memorial Hospital and also University Hospital of North Durham.

    Contact email: Tel: 0191 3332521

    • Dumfries - Dumfries and Galloway Royal Infirmary.
    • Ipswich - Ipswich Hospital.

    Contact email: Tel: 01473 702 486 / 2151

    • Liverpool - Liverpool Women's Hospital.

    Contact email: Tel: 0151 702 4496 or 07971515813

    • London -
      • Chelsea & Westminster Hospital.
      • King's College Hospital.
      • Royal London Hospital.

    Contact email: Tel: 020 3594 2405 or 07552267937

      • University College London Hospital.
      • West Middlesex University Hospital
        Contact email: Tel: 020 8321 5427.
    • Norwich - Norfolk & Norwich University Hospital.

    Contact email: Tel: 01603 288530

    • Oxford - John Radcliffe Hospital.

    Contact email: Tel: 01865 572258

    • Portsmouth - Queen Alexandra Hospital.

    Contact email: Tel: 02392286000 Extension 4378 Bleep 1732

    • Southampton - Southampton General Hospital.
    • South Tees - The James Cook University Hospital.

    Contact email: Tel: 01642 835913

    • Sunderland - Sunderland Royal Hospital.
    • Sussex -
      • St. Richard's Hospital.

    Contact email: or Tel: 01243 788122 Extension 32768

      • Worthing Hospital.

    Contact email: Tel: 01903 205111 Extension 84681

    • Swansea - Singleton Hospital.

    Contact email: Tel: 07773243257

    • Telford - Princess Royal Hospital.

    Contact email: Tel: 01952 565939

    • Wigan - Royal Albert Edward Infirmary.

    How can I be referred to take part?

    You may be able to take part in the CERM trial if:

    • you are aged between 18 and 42
    • you have experienced 2 or more first trimester miscarriages in a row
    • your miscarriages are unexplained (a cause has not been found)

    Please contact one of the above participating sites to discuss how you can be referred to take part, or ask your GP to refer you, via the NHS choose and book system, to Professor Siobhan Quenby at the recurrent miscarriage clinic at: University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX

    Below is a diagram showing an overview of the CERM trial:

    Flow chart of CERM participant pathway

    Please note: 'CERM B' activities only relate to participants at University Hospital Coventry & Warwickshire (who have consented to CERM B)


    Jonathan Guck
    Trial Manager

    Email: cerm at warwick dot ac dot uk

    Warwick Clinical Trials Unit
    Warwick Medical School
    University of Warwick
    Gibbet Hill Road
    CV4 7AL