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Co-enrolment studies

In agreement with the SOS Trial Management Group and the individual study teams, the below studies allow co-enrolment:

ADAPT-Sepsis Biomarker-guided duration of antibiotic treatment in hospitalised patients with suspected sepsis.
AspiFlu Aspergillosis in patients with severe influenza
A-STOP Antifungal stewardship opportunities with rapid tests for fungal infection in critically ill patients.
BIS The use of Bispectral Index monitoring to assess depth of sedation in patients with traumatic brain injury (BIS-TBI)
BLING III The Beta-Lactam InfusioN Group
A phase III randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients
BONANZA

Brain Oxygen Neuromonitoring In Australia And New Zealand Assessment

CIRCA Critical Illness Related Cardiac Arrest (CIRCA): an investigation of the incidence and outcome of cardiac arrest within Intensive Care Units in the United Kingdom.
CRYOSTAT2 Early cryoprecipitate in trauma.
GenOMICC Genetics Of Mortality In Critical Care
Golden Hour Brain Biomarkers after trauma study.
HEMOTION HEMOglobin transfusion threshold in Traumatic brain Injury OptimizatioN
IMPACT-2 Bacteriophage, Multi-Drug Resistant Escherichia coli and MicroRNA dynamics in the gut microbiome of critically ill patients
MARCH Mucoactives in Acute Respiratory failure: Carbocisteine and Hypertonic saline
MAST Management of Seizures after Traumatic Brain Injury
Optic-ICP Optic Nerve Sheath Ultrasound to Track changes in Intra Cranial Pressure
ORiF The Operative Rib Fixation Study
PHIND Clinical evaluation of a POC assay to identify PHenotypes IN the Acute Respiratory Distress Syndrome
PQIP Perioperative Quality Improvement Programme
PuPIL

Pupillometer utilisation for Predicting Intracranial pressure in Liverpool/ PuPIL

REALIST

Repair of Acute Respiratory Distress Syndrome by Stromal Cell

REBOA

Resuscitative Endovascular Balloon Occlusion of the Aorta for trauma

RED DiAMOND

Near Infra-RED Cerebral Spectroscopy in the DIrection And early MONitoring of therapy in patients with tRaUmatic Brain injurY

SARIPOC Pragmatic randomised controlled trial of molecular point-of-care testing for respiratory
pathogens versus routine clinical care in critically ill adults with Pneumonia: SARIPOC
TARDIS

Traumatic Brain Injury Associated Radiological DVT Incidence and Significance (TARDIS) Study

VITDALIZE Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency. The UK arm of an international multicentre, placebo-controlled, phase III, double-blind trial.
UK-ROX Intensive Care Unit Randomised Trial Comparing Two Approaches to OXygen Therapy