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Co-enrolment studies

In agreement with the SOS Trial Management Group and the individual study teams, the below studies allow co-enrolment:

ADAPT-Sepsis Biomarker-guided duration of antibiotic treatment in hospitalised patients with suspected sepsis.
AspiFlu Aspergillosis in patients with severe influenza
A-STOP Antifungal stewardship opportunities with rapid tests for fungal infection in critically ill patients.
BIS The use of Bispectral Index monitoring to assess depth of sedation in patients with traumatic brain injury (BIS-TBI)
BLING III The Beta-Lactam InfusioN Group
A phase III randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients

Brain Oxygen Neuromonitoring In Australia And New Zealand Assessment

CIRCA Critical Illness Related Cardiac Arrest (CIRCA): an investigation of the incidence and outcome of cardiac arrest within Intensive Care Units in the United Kingdom.
CoMiTED Conservative Management in Traumatic Pneumothoraces in the Emergency Department (CoMiTED): A Randomised Controlled Trial
CPS Efficacy of instilled saline in conjunction with chest Physiotherapy on Secretion clearance in adults diagnosed with a Ventilator Acquired Pneumonia
CRASH-4 Clinical randomisation of an anti-fibrinolytic in symptomatic mild head injury in older adults
CRYOSTAT2 Early cryoprecipitate in trauma.
ERASER Early Rib Analgesia with SERratus
GenOMICC Genetics Of Mortality In Critical Care
Golden Hour Brain Biomarkers after trauma study.
HEMOTION HEMOglobin transfusion threshold in Traumatic brain Injury OptimizatioN

Bacteriophage, Multi-Drug Resistant Escherichia coli and MicroRNA dynamics in the gut microbiome of critically ill patients


Evaluation of Intracranial Pressure time dose by the new Integra Cerelink ICP monitor


Inpatient adoption of Cystatin C eGFR in guiding patient management


Remote rehabilitation after intensive care

MARCH Mucoactives in Acute Respiratory failure: Carbocisteine and Hypertonic saline
MAST Management of Seizures after Traumatic Brain Injury
Mec-ROX Oxidative stress, redox status and surfactant metabolism in mechanically ventilated patients receiving different approaches to oxygen therapy
Optic-ICP Optic Nerve Sheath Ultrasound to Track changes in Intra Cranial Pressure
ORiF The Operative Rib Fixation Study
PHIND Clinical evaluation of a POC assay to identify PHenotypes IN the Acute Respiratory Distress Syndrome
PQIP Perioperative Quality Improvement Programme
Protocol 30 Assessment of cerebral oedema, regional cerebral blood flow, oxygenation and glucose metabolism in severe head injury using positron emission tomography and magnetic resonance imaging

Pupillometer utilisation for Predicting Intracranial pressure in Liverpool/ PuPIL


Repair of Acute Respiratory Distress Syndrome by Stromal Cell


Resuscitative Endovascular Balloon Occlusion of the Aorta for trauma


Near Infra-RED Cerebral Spectroscopy in the DIrection And early MONitoring of therapy in patients with tRaUmatic Brain injurY

SARIPOC Pragmatic randomised controlled trial of molecular point-of-care testing for respiratory
pathogens versus routine clinical care in critically ill adults with Pneumonia: SARIPOC
SepTIC Sepsis Trials in Critical Care
SHORTER A randomised controlled trial of SHORT duration antibiotic thERapy for critically ill patients with sepsis
SIGNET Statins for Improving orGaN outcomE in Transplantation
SWiFT Study of Whole blood in Frontline Trauma.
TAP Evaluation of BE1116 (4F-PCC) in patients with traumatic injury and acute major bleeding to improve survival

Traumatic Brain Injury Associated Radiological DVT Incidence and Significance (TARDIS) Study


Targeted perfusion based haemodynamic management in critically ill patients using urethral perfusion


Transcutaneous Pulse Oximetry Brain Monitoring Study (UK)


Traumatic brain injury related changes in military veterans


A research study to investigate the role of Extracellular Vesicles in the Pathogenesis of Acute Respiratory Distress Syndrome

VITDALIZE Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency. The UK arm of an international multicentre, placebo-controlled, phase III, double-blind trial.
UK-ROX Intensive Care Unit Randomised Trial Comparing Two Approaches to OXygen Therapy