Publications and media coverage
Find details of our published research as well as interviews with the media on our work and the fiield of chronotherapy generally.
Recent publications
- Dallmann R, Okayr A, Levi F: Dosing Time makes the Poison: Circadian Regulation of Pharmacotherapy . Trends inmol Med 2016, 22 (5): 430-445.
- Lévi F.A., Boige V.; Hebbar M.; Smith D.; Lepère C.; Focan C.; Karaboué A.; Guimbaud R.; Carvalho C.; Tumolo S.; Innominato P.; Ajavon Y.; Truant S.; Castaing D.; De Baere T.; Kunstlinger F.; Bouchahda M.; Afshar M., Rougier P.; Adam R.; Ducreux M., on behalf of all the trial investigators, and ARTBC International: Conversion to resection of liver metastases from colorectal cancer with hepatic artery infusion of combined chemotherapy and systemic cetuximab in multicenter trial OPTILIV. Ann Oncol, 2016, 27 (2): 267-274.
- Dulong S, Ballesta A, Okyar A, Levi F: Identification of circadian determinants of cancer chronotherapy through in vitro chronopharmacology and mathematical modeling. Mol Cancer Ther 2015, Jul 3. pii: molcanther.0129.2015. [Epub ahead of print]
- Natale V, Innominato PF, Boreggiani M, Tonetti L, Filardi M, Parganiha A, Fabbri M, Martoni M, Lévi F. The difference between in bed and out of bed activity as a behavioral marker of cancer patients: A comparative actigraphic study. Chronobiol Int. 2015 Jul 9:1-9. [Epub ahead of print]
- Feillet C., Krusche P., Tamanini F., Janssens R., Downey M, Martin P., Teboul M., Saito S., Lévi F., Bretschneider T., van der Horst G.T.J., Delaunay F.,. Rand D. A. Phase-locking and multiple attractors for the coupled mammalian clock and cell cycle. Proc Natl Acad Sci USA 2014 Jul 8;111(27):9828-33.
- Innominato P.F., Spiegel D., Ulusakarya A., Giacchetti S., Bjarnason G.A., Lévi F., Palesh O Subjective sleep and overall survival in chemotherapy-naïve patients with metastatic colorectal cancer. Sleep Medicine 2015, 16:391–398
- Innominato PF, Roche VP, Palesh OG, Ulusakarya A, Spiegel D, Lévi FA. The circadian timing system in clinical oncology. Ann Med. 2014 Jun;46(4):191-207.
- Lévi F, Dugué PA, Innominato P, Karaboué A, Dispersyn G, Parganiha A, Giacchetti S, Moreau T, Focan C, Waterhouse J, Spiegel D, on behalf of the ARTBC Chronotherapy Group: Wrist actimetry circadian rhythm as a robust predictor of colorectal cancer patients survival. Chronobiol Int. 2014 Oct;31(8):891-900
- Costa MJ, Finkenstädt BF, Gould PD, Foreman J, Halliday K, Hall A, Roche V, Lévi F, Rand DA; Inference on periodicity of circadian time series. Biostatistics 2013, 2013;14(4):792-806.
- Lévi F., Mosekilde E., Rand D. A.: Advancing systems medicine and therapeutics through biosimulation. Interface Focus, 2011, 1: 3-6.
Media coverage
- Chemotherapy could work twice as well if given at the right time
- The Conversation: Giving fish their medicine at the right time can make all the difference 20 July 2015
- BBC News Online: The science of timing drugs to our body clock 13 May 2014