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Eligibility Criteria

Inclusion Criteria:

  • Women, age >18 years
  • Histologically confirmed invasive or non-invasive primary breast cancer scheduled for surgical excision
  • Considered high risk of developing shoulder problems after surgery defined by one or more of the following:
    • planned axillary node clearance (ANC);
    • planned radiotherapy (RT);
    • existing shoulder problems (based upon PROSPER screening criteria);
    • obesity defined as BMI (greater than or equal to) >30;
    • any subsequent axillary surgery related to primary surgery, e.g. ANC conducted after sentinel lymph node biopsy (SLNB)
  • Willing and able to comply with the protocol
  • Written informed consent
  • Any later decision (made within 6 weeks of surgery) to refer to RT
  • Women who have had previous breast surgery (e.g. excision of benign tumour or breast cyst) are eligible for invitation;
  • Women who have had previous contralateral (opposite side) mastectomy are eligible for invitation.

Exclusion Criteria

  • Males
  • Women having immediate reconstructive surgery
  • Women having SLNB with or without breast surgery unless have other high risk criteria
  • Women having bilateral breast surgery
  • Evidence of known metastatic disease at time of recruitment

This information is taken from Version 1.0 of the PROSPER Protocol (dated 01 Jun 2015)



Contact the Trial Office:

Please direct all general enquiries to:

prosper at warwick dot ac dot uk