Results & Publications
The PROSPER trial results can be accessed using the links below:
The main trial results are published here:
Bruce J, Mazuquin B, Canaway A, Hossain A, Williamson E, Mistry P, et. al. Exercise versus usual care after non-reconstructive breast cancer surgery (UK PROSPER): multicentre randomised controlled trial and economic evaluation BMJ2021; 375:e066542 doi: 10.1136/bmj-2021-06654
The NIHR HTA final trial report (including a plain language explanation of the findings) can be accessed here.
Bruce J, Mazuquin B, Mistry P, Rees S, Canaway A, Hossain A, Williamson E, Padfield EJ, Lall R, Richmond H, Chowdhury L, Lait C, Petrou S, Booth K, Lamb SE, Vidya R, Thompson AM. Exercise to prevent shoulder problems after breast cancer surgery: the PROSPER RCT. Health Technol Assess. 2022 Feb;26(15):1-124. doi: 10.3310/JKNZ2003. PMID: 35220995.
The trial protocol is published here:
Bruce J, Williamson E, Lait C, Richmond H, Betteley L, Lall R, Petrou S, Rees S, Withers EJ, Lamb SE, Thompson AM; PROSPER Study Group. Randomised controlled trial of exercise to prevent shoulder problems in women undergoing breast cancer treatment: study protocol for the prevention of shoulder problems trial (UK PROSPER). BMJ Open. 2018 Mar 23;8(3):e019078. doi: 10.1136/bmjopen-2017-019078. PMID: 29574439; PMCID: PMC5875650.
Information about the development of the exercise intervention can be found here:
Richmond H, Lait C, Srikesavan C, Williamson E, Moser J, Newman M, Betteley L, Fordham B, Rees S, Lamb SE, Bruce J; PROSPER Study Group. Development of an exercise intervention for the prevention of musculoskeletal shoulder problems after breast cancer treatment: the prevention of shoulder problems trial (UK PROSPER). BMC Health Serv Res. 2018 Jun 18;18(1):463. doi: 10.1186/s12913-018-3280-x. PMID: 29914494; PMCID: PMC6006920.
The qualitative sub-study results are available here:
Rees S, Mazuquin B, Richmond H, Williamson E, Bruce J; UK PROSPER Study Group. Role of physiotherapy in supporting recovery from breast cancer treatment: a qualitative study embedded within the UK PROSPER trial. BMJ Open. 2021 May 11;11(5):e040116. doi: 10.1136/bmjopen-2020-040116. PMID: 33980512; PMCID: PMC8118023.
A systematic review of economic evaluations is available here:
Rees S, Mazuquin B, Richmond H, Williamson E, Bruce J; UK PROSPER Study Group. Role of physiotherapy in supporting recovery from breast cancer treatment: a qualitative study embedded within the UK PROSPER trial. BMJ Open. 2021 May 11;11(5):e040116. doi: 10.1136/bmjopen-2020-040116. PMID: 33980512; PMCID: PMC8118023.