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KOPS — Knee Outcome Prediction Study

Ten per cent of the U.K. population over the age of 55 suffer from pain and decreased quality of life as a result of knee osteoarthritis (OA). Total Knee Arthroplasty (TKA) is a treatment that has a proven benefit; however a proportion of people, possibly as high as one in six, have less satisfactory outcomes after surgery. The type of operation or the type and intensity of the rehabilitation programme does not appear to account for all the variability in outcome, and there is growing evidence that patient factors (e.g. age, other medical problems) affects outcome.

We want to establish...

  • Which patient factors effect outcome after Total Knee Replacement?
  • Are there combinations of factors that are particularly important?
  • How do we relate this to counselling before operations?
  • Can we target any of these factors to improve overall outcome?

Experimental Plan


KOP Study
Warwick Medical School
Clinical Sciences Research Laboratories
Clifford Bridge Road

We plan to recruit approximately 500 patients who are going to have a Total Knee Replacement for knee osteoarthritis. We will then measure various patient factors before the operation (such as age, other medical problems, and coping strategies) using standardised questionnaires. Patients will be followed for one year after their operation to enable us to measure outcome in terms of how satisfied they are, how well the knee is performing, and what their general health is like. We will use this information to produce a tool that predicts individual outcome for this operation.


Recruitment is planned to start in February 2013.
NHR Research Ethics Committees approval reference number 12/EM/0336

Chief Investigator

Damian Griffin
Professor of Trauma and Orthopaedic Surgery

KOPS Coordinator

Mr Tim Barlow
Tel 02476 968620

Collaborating Investigators

Mark Dunbar Clinical Lecturer in Trauma and Orthopaedics, Warwick Medical School, University of Warwick and University of Oxford

Simon Gates Professor of Research Methodology, Warwick Medical School, University of Warwick

Collaborating Centres

University Hospitals Coventry and Warwickshire NHS Trust
T Barlow, D Griffin
Rugby St Cross Hospital
T Barlow, D Griffin
George Elliot Hospital
R Reddy
Warwick Hospital
Jonathon Waite
BMI Meridan Hospital
Claire Franklin
Nuffield Hospital
Jill White