A multicentre randomised phase III trial comparing PET-CT guided watch and wait policy versus planned neck dissection for the management of locally advanced (N2/N3) nodal metastases in patients with head and neck squamous cancer
- This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme (project number 06/302/129).
Any opinions expressed here are those of the authors and do not necessarily reflect those of the HTA, NIHR, NHS or the Department of Health.
Aim of the Project
To compare the efficacy of a PET-CT guided watch and wait policy with the current practice of planned neck dissection on overall survival, disease-specific survival, recurrence, quality of life and cost-effectiveness in the management of advanced (N2 or N3) nodal metastasis in patients treated with chemo/radiotherapy (CRT) for their head and neck squamous carcinoma (HNSCC) primary.
Oxfordshire REC A
Start Date: 01/04/2007, End Date: 31/03/2015. The study is now closed to recruitment.
|Professor Hisham Mehanna||University of Birmingham||Chief Investigator||
Consultant Head-Neck and Thyroid Surgeon & Honorary Professor
|Professor Janet Dunn||University of Warwick||Non-clinical Lead applicant||Professor of Clinical Trials and Head of Cancer Trials Deputy Director WMS Clinical Trials Unit|
|Dr Wai-Lup Wong||Mount Vernon Hospital||Co-applicant||Radiology|
|Professor Chris Nutting||Royal Marsden NHS Foundation Trust||Co-applicant||Clinical Oncology|
|Professor Chris McCabe||University of Leeds||Co-applicant||Health Economics|
|Professor Ken Maclennan||Leeds General Infirmary||Co-applicant||Histopathology|
|Mrs Sheila Fisher||University of Leeds||Co-applicant||Maxillofacial Surgery|
|Ms Joy Rahman||University of Warwick||Trial Co-ordinator|
|Mr Chris McConkey||University of Warwick||Statistician|
|Mr Dharmesh Patel||University of Warwick||Trial Administrator|
|Ms June Jones||
University of Birmingham
|Head and Neck Centre|
|Heart of England NHS Foundation Trust|
Publications/Presentations to Date
Health Technology Assessment Final Report:
PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography computerised tomography-guided watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer
Health Technology Assessment Volume: 21, Issue: 17, Published in April 2017
Mehanna et. al, for the PET-NECK Trial Management Group, PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer | NEJM
New England Journal of Medicine April 2016; 374:1444-1454
PET-NECK: A multi-centre randomised Phase III trial comparing PET-CT guided active surveillance with planned neck dissection in the management of locally advanced HNSCC, CLRN, March 2012
- Prof Janet Dunn Professor of Clinical Trials and Head of Cancer Trials Deputy Director WMS Clinical Trials Unit
- Professor Hisham Mehanna, Consultant Head-Neck and Thyroid Surgeon & Honorary Professor