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PET-Neck

A multicentre randomised phase III trial comparing PET-CT guided watch and wait policy versus planned neck dissection for the management of locally advanced (N2/N3) nodal metastases in patients with head and neck squamous cancer

Acknowledgements

  • This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme (project number 06/302/129).

Any opinions expressed here are those of the authors and do not necessarily reflect those of the HTA, NIHR, NHS or the Department of Health.

Aim of the Project

To compare the efficacy of a PET-CT guided watch and wait policy with the current practice of planned neck dissection on overall survival, disease-specific survival, recurrence, quality of life and cost-effectiveness in the management of advanced (N2 or N3) nodal metastasis in patients treated with chemo/radiotherapy (CRT) for their head and neck squamous carcinoma (HNSCC) primary.

Ethical Approval

Oxfordshire REC A

Project Schedule

Start Date: 01/04/2007, End Date: 31/03/2015. The study is now closed to recruitment.

Lead Investigators

Name Establishment Role Speciality
Professor Hisham Mehanna University of Birmingham Chief Investigator

Consultant Head-Neck and Thyroid Surgeon & Honorary Professor

Professor Janet Dunn University of Warwick Non-clinical Lead applicant Professor of Clinical Trials and Head of Cancer Trials Deputy Director WMS Clinical Trials Unit
Dr Wai-Lup Wong Mount Vernon Hospital Co-applicant Radiology
Professor Chris Nutting Royal Marsden NHS Foundation Trust Co-applicant Clinical Oncology
Professor Chris McCabe University of Leeds Co-applicant Health Economics
Professor Ken Maclennan Leeds General Infirmary Co-applicant Histopathology
Mrs Sheila Fisher University of Leeds Co-applicant Maxillofacial Surgery

 

Project team

Name Establishment Role
Ms Joy Rahman University of Warwick Trial Co-ordinator
Mr Chris McConkey University of Warwick Statistician
Mr Dharmesh Patel University of Warwick Trial Administrator
Ms June Jones

University of Birmingham

Research Nurse
 

Project collaborators

Head and Neck Centre
Heart of England NHS Foundation Trust

 

Publications/Presentations to Date

PET-NECK: Setting up a collaborative clinical trial in a rare disease site. Society of Clinical Trials, May 2008.(PDF Document)

PET-NECK: A multi-centre randomised Phase III trial comparing PET-CT guided active surveillance with planned neck dissection in the management of locally advanced HNSCC, CLRN, March 2012(PDF Document)

PET-NECK logo
Key people
  • Prof Janet Dunn Professor of Clinical Trials and Head of Cancer Trials Deputy Director WMS Clinical Trials Unit
  • Professor Hisham Mehanna, Consultant Head-Neck and Thyroid Surgeon & Honorary Professor
  • Ms Joy Katherine Rahman Clinical Trials Co-ordinator
  • Mr Dharmesh Kumar Patel Trial Administrator
Enquiries contact

Mr Dharmesh Kumar Patel, BSc.,

Trial Administrator,

Tel: 44(0)02476 572 725;

Fax: +44(0)2476 151 586

Email: D.K.Patel@warwick.ac.uk

Links