Co-enrolment studies
In agreement with the SOS Trial Management Group and the individual study teams, the below studies allow co-enrolment:
| ABBRUPT |
A randomised controlled trial to investigate clinical and cost effectiveness of Amiodarone vs Beta Blockade for new onset atrial fibRillation in icU - a Pragmatic sTudy |
| ADAPT-Sepsis | Biomarker-guided duration of antibiotic treatment in hospitalised patients with suspected sepsis. |
| AspiFlu | Aspergillosis in patients with severe influenza |
| A-STOP | Antifungal stewardship opportunities with rapid tests for fungal infection in critically ill patients. |
| BIS | The use of Bispectral Index monitoring to assess depth of sedation in patients with traumatic brain injury (BIS-TBI) |
| BLING III | The Beta-Lactam InfusioN Group A phase III randomised controlled trial of continuous beta-lactam infusion compared with intermittent beta-lactam dosing in critically ill patients |
| BONANZA |
Brain Oxygen Neuromonitoring In Australia And New Zealand Assessment |
| CIRCA | Critical Illness Related Cardiac Arrest (CIRCA): an investigation of the incidence and outcome of cardiac arrest within Intensive Care Units in the United Kingdom. |
| CoMiTED | Conservative Management in Traumatic Pneumothoraces in the Emergency Department (CoMiTED): A Randomised Controlled Trial |
| CoReCCT |
The Confederation of Respiratory Critical Care Trials (Consists of: Awake Prone, NAVA, PROTECT Airways and RELEASE) |
| CPS | Efficacy of instilled saline in conjunction with chest Physiotherapy on Secretion clearance in adults diagnosed with a Ventilator Acquired Pneumonia |
| CRASH-4 | Clinical randomisation of an anti-fibrinolytic in symptomatic mild head injury in older adults |
| CRYOSTAT2 | Early cryoprecipitate in trauma. |
| ERASER | Early Rib Analgesia with SERratus |
| FRECycl-D | Does in-bed Cycling delivered within 48 hours of mechanical ventilation, rEduce the occurrence of Delirium in critically ill patients (FRECycl-D): A mixedmethods Feasibility Randomised controlled trial protocol. |
| GenOMICC | Genetics Of Mortality In Critical Care |
| Golden Hour | Brain Biomarkers after trauma study. |
| HEMOTION | HEMOglobin transfusion threshold in Traumatic brain Injury OptimizatioN |
| IMPACT-2 |
Bacteriophage, Multi-Drug Resistant Escherichia coli and MicroRNA dynamics in the gut microbiome of critically ill patients |
| ImPETO |
Evaluation of Intracranial Pressure time dose by the new Integra Cerelink ICP monitor |
| InCyst |
Inpatient adoption of Cystatin C eGFR in guiding patient management |
| INSIGHT |
Evaluation of a Point-of-Care Ultrasound Training Programme in Achieving Competency for Critical Care Practitioners in a Whole-Body Ultrasound Scan |
| iRehab |
Remote rehabilitation after intensive care |
| MARCH | Mucoactives in Acute Respiratory failure: Carbocisteine and Hypertonic saline |
| MAST | Management of Seizures after Traumatic Brain Injury |
| Mec-ROX | Oxidative stress, redox status and surfactant metabolism in mechanically ventilated patients receiving different approaches to oxygen therapy |
| Neuroinflammatory study |
Neuroinflammatory signature of acute brain injury |
| Optic-ICP | Optic Nerve Sheath Ultrasound to Track changes in Intra Cranial Pressure |
| ORiF | The Operative Rib Fixation Study |
| PHIND | Clinical evaluation of a POC assay to identify PHenotypes IN the Acute Respiratory Distress Syndrome |
| PQIP | Perioperative Quality Improvement Programme |
| Protocol 30 | Assessment of cerebral oedema, regional cerebral blood flow, oxygenation and glucose metabolism in severe head injury using positron emission tomography and magnetic resonance imaging |
| PuPIL |
Pupillometer utilisation for Predicting Intracranial pressure in Liverpool/ PuPIL |
| REALIST |
Repair of Acute Respiratory Distress Syndrome by Stromal Cell |
| REBOA |
Resuscitative Endovascular Balloon Occlusion of the Aorta for trauma |
| RED DiAMOND |
Near Infra-RED Cerebral Spectroscopy in the DIrection And early MONitoring of therapy in patients with tRaUmatic Brain injurY |
| SARIPOC | Pragmatic randomised controlled trial of molecular point-of-care testing for respiratory pathogens versus routine clinical care in critically ill adults with Pneumonia: SARIPOC |
| SepTIC | Sepsis Trials in Critical Care |
| SHORTER | A randomised controlled trial of SHORT duration antibiotic thERapy for critically ill patients with sepsis |
| SIGNET | Statins for Improving orGaN outcomE in Transplantation |
| SWiFT | Study of Whole blood in Frontline Trauma. |
| TAP | Evaluation of BE1116 (4F-PCC) in patients with traumatic injury and acute major bleeding to improve survival |
| TARDIS |
Traumatic Brain Injury Associated Radiological DVT Incidence and Significance (TARDIS) Study |
| TARGET-UP |
Targeted perfusion based haemodynamic management in critically ill patients using urethral perfusion |
| T-POT |
Transcutaneous Pulse Oximetry Brain Monitoring Study (UK) |
| UKAR | UK Antimicrobial Registry Study |
| UNTANGLE |
Traumatic brain injury related changes in military veterans |
| VESPER |
A research study to investigate the role of Extracellular Vesicles in the Pathogenesis of Acute Respiratory Distress Syndrome |
| VITDALIZE | Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency. The UK arm of an international multicentre, placebo-controlled, phase III, double-blind trial. |
| UK-ROX | Intensive Care Unit Randomised Trial Comparing Two Approaches to OXygen Therapy |