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Publication: STRESS-L Trial Results - 25 October 2023

The main clinical results from the trial have now been published in JAMA and can be viewed here.

Whitehouse T, Hossain A, Perkins GD, et al. Landiolol and Organ Failure in Patients With Septic Shock: The STRESS-L Randomized Clinical Trial. JAMA. Published online October 25, 2023. doi:10.1001/jama.2023.20134

STRESS-L Investigator Meeting 14 June 2021

We would like to say a huge thank you to everyone who attended the STRESS-L virtual Investigator Meeting. We hope you found the meeting informative and useful to help with recruitment and answer any questions you might have. A special thank you to Prof Ingeborg Welters (PI) at Royal Liverpool and Dr Sam Waddy (PI) at Derriford Hospital for your insight and top tips for recruiting to the trial. We would also like to thank our PPI representative Lee Bettles for being honest and open regarding his real life experience of having sepsis and why STRESS-L matters.

For anyone who was unable to attend the meeting a record of the meeting can be downloaded here. Link opens in a new windowLink opens in a new window

Slides from the meeting can be downloaded here.

First patient recruited post COVID 15.10.20

A big thank you to the Derriford Hospital team who recruited the first patient post COVID today. Thank you for your hard work and screening efforts.

18 sites have started recruitment 14.10.20

18 hospital sites have now restarted recruitment for STRESS-L. Thank you to all for your persistence and commitment to enabling a smooth restart at your site. We greatly look forward to working with you all again.

Recruitment has restarted at Musgrove Park, Sunderland Royal and Royal Liverpool 10.09.20

Thank you to all of the teams at Musgrove Park, Sunderland Royal and Royal Liverpool for your help in preparing for the restart of recruitment to STRESS-L. Great to have you back and working with you again.

Recruitment has restarted at UCLH and Derriford Hospital! 03.09.2020

Welcome back on board UCLH and Derriford Hospital! Thank you very much for your hard work in preparing to restart recruitment locally at your site. We look forward to working with you again.

STRESS-L is now re-open to recruitment 21.08.2020

We are delighted to announce STRESS-L has received confirmation to restart recruitment. Thank you to all of our recruitment sites for your patience whilst we have prepared for the restart. We very much look forward to working with you again shortly.

The STRESS-L trial team will contact each site individually to provide the green light to locally restart recruitment.

Please do not restart screening or recruitment until you have received this greenlight.

Further details of requirements for the restart including refresher training can be found here. Link opens in a new window

All trial documentation for site staff has been uploaded to the website and can be downloaded hereLink opens in a new window

STRESS-L is suspended during COVID-19 pandemic 18.03.2020

As of 18 March 2020, STRESS-L has been temporarily halted to screening and recruitment until further notice. This decision has come following recent NIHR guidanceLink opens in a new window to move towards supporting the Urgent Public Health research portfolio for COVID-19. The NIHR EME remain fully supportive of the trial and recruitment will recommence when are in the position to do so.

Sites are asked to move all IMP stored on ICU to pharmacy as soon as possible to ensure essential temperature monitoring continues and inform the STRESS-L trial team when this has been completed.

We ask recruitment sites to continue with essential safety reporting for STRESS-L patients and to suspend all other trial activity. The STRESS-L trial team will suspend all non-urgent requests to recruitment sites during this time. We do not wish to pose any burden on research staff during this time but if recruitment sites feel they have capacity to continue with data queries during this time please let the STRESS-L trial team know and we will continue to work through these with you.

Thank you to all of our recruitment sites for your hard work on the STRESS-L trial. We look forward to working with you again soon. Best wishes to all.

New site open in February 2020

Welcome to Royal Victoria Infirmary in Newcastle who opened to recruitment at the end of February 2020. We look forward to working with you. Click here to see a list of all sites open to recruitment.

STRESS-L Recruitment milestone 11th February 2020

What a fantastic start to 2020 we have had for recruitment. A big thank you to all of our teams who have recruited over the last few weeks to hit a recruitment milestone of 100 patients!! Congratulations to the team at Musgrove Park Hospital for helping us to achieve this!


New sites open to recruitment January 2020

We opened 3 new sites to recruitment during January 2020. Welcome on board Queen Elizabeth Hospital Glasgow, St George's Hospital London and Royal Sussex Country Hospital Brighton! Happy recruiting!

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Warwick Clinical Trials Unit
Warwick Medical School
University of Warwick
Gibbet Hill Road