The STRESS-L clinical trial results can be accessed here:

Whitehouse T, Hossain A, Perkins GD, et al. Landiolol and Organ Failure in Patients With Septic Shock: The STRESS-L Randomized Clinical Trial. JAMA. Published online October 25, 2023. doi:10.1001/jama.2023.20134

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The results of a sub-investigation completed as part of the STRESS-L trial can be accessed here:

Thomas JL, McGee KC, Hossain A, Perkins GD, Gordon AC, Young D, McAuley D, Singer M, Lall R, Kramaric T, Lord JM, Whitehouse T, Mur LAJ; STRESS-L. collaborators. The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study. Intensive Care Med Exp. 2025 Jan 22;13(1):9. doi: 10.1186/s40635-024-00708-6. PMID: 39841388Link opens in a new window.

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The STRESS-L trial protocol is published here:

Lall R, Mistry D, Skilton E, et al Study into the reversal of septic shock with landiolol (beta blockade): STRESS-L Study protocol for a randomised trial, BMJ Open 2021;11:e043194. doi: 10.1136/bmjopen-2020-043194

https://bmjopen.bmj.com/content/11/2/e043194.long 

Enquiries:

 
Email: STRESS-L@warwick.ac.uk

Address:
Warwick Clinical Trials Unit
Warwick Medical School
University of Warwick
Gibbet Hill Road
Coventry
CV4 7AL