A systematic review published in The Cochrane Library finds that in well-nourished adults current evidence does not support selenium for preventing heart disease.

The review suggests that taking selenium supplements does not reduce a person’s risk of developing heart disease, although most evidence is currently limited to healthy American adults.

Diet is a key factor influencing heart disease risk. Selenium is one dietary element that could potentially play a role in preventing heart disease by protecting against oxidative stress and inflammation.

It is a common food supplement and is often given to guard against heart disease, but with little evidence that it works. In addition, there is concern that consuming too much selenium could increase a person’s risk of type 2 diabetes in individuals with high selenium status.

The researchers analysed data from 12 trials that together involved 19,715 people. Compared to placebos, taking selenium supplements did not lead to any statistically significant difference in the risk of death due to heart disease or any cause, or in the occurrence of heart problems.

Although supplements were associated with a small increase in the risk of type 2 diabetes, this increase was not large enough to be statistically significant. Side effects included alopecia and dermatitis.

“The limited evidence available at this time does not support the use of selenium supplements in the primary prevention of heart disease in well-nourished populations,” said one of the authors Saverio Stranges of Warwick Medical School at the University of Warwick in Coventry, UK. “Taking selenium supplements is probably neither beneficial nor harmful, but given the lack of trials to date, we cannot rule out some low level of increased risk of type 2 diabetes, at least in individuals with high selenium status.”

Most current evidence on selenium and heart disease risk is limited to American adults who are already getting adequate levels of selenium in their daily diets. The trials the researchers reviewed involved healthy individuals rather than groups that might be predisposed to selenium deficiency. “We need to know what effect selenium supplements have in less well-nourished populations where dietary intake of the element is lower,” said Stranges. “However, the indiscriminate and widespread use of selenium supplements in individuals and populations with adequate or high selenium status is not justified and should not be encouraged.”

Notes for editors

Full citation: Rees K, Hartley L, Day C, Flowers N, Clarke A, Stranges S. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database of Systematic Reviews 2013, Issue 1. Art. No.: CD009671. DOI: 10.1002/14651858.CD009671.pub2.

Acknowledgements: This project was funded by the National Institute for Health Research Systematic Reviews Programme.

Author Interviews: Dr. Saverio Stranges, MD, PhD, Associate Professor of Cardiovascular Epidemiology at Warwick Medical School, University of Warwick, UK, will be available for interviews.

Dr Stranges can be contacted on +44 (0)2476 151153 or s dot stranges at warwick dot ac dot uk

Or contact Anna Blackaby, University of Warwick International Press Officer and Faculty of Science Press Officer on a dot blackaby at warwick dot ac dot ukor +44 (0)2476 575910.

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Dr. Saverio Stranges, MD, PhD, Associate Professor of Cardiovascular Epidemiology at Warwick Medical School, University of Warwick, UK, will be available for interviews.Dr Stranges can be contacted on +44 (0)2476 151153 or s dot stranges at warwick dot ac dot uk

Or contact Anna Blackaby, University of Warwick International Press Officer and Faculty of Science Press Officer on a dot blackaby at warwick dot ac dot ukor +44 (0)2476 575910.