Study Overview

The REGAIN study aimed to find out which of two treatments is better for helping people recover after being in hospital with COVID-19.

People recovering from covid-19 often feel weak, breathless and tired. Some people are also worried and frightened. For most people, these problems will get better on their own, but for some people, they may continue for a long time after leaving hospital (long-covid / post-covid-19 condition).

For people who are still struggling months after being ill with covid-19, we wanted to find out which of two treatments is better for helping people recover:

• A single online session of exercise advice and support
• An 8 week online exercise and support programme

585 adults living in the UK took part in the study between January 2021 and September 2023.

Primary Outcome: Health-related quality of life; Patient-Reported Outcome Measurement Information System (PROMIS) Preference Score (PROPr) [PROMIS^® 29+2 Profile v2.1 (PROPr)] reported three months after being allocated to one of the two treatments.