The Computing and Advanced Microscopy Development Unit (CAMDU) at Warwick Medical School houses a suite of state-of-the-art imaging and computational resources. The facility is equipped to support advanced research in biomedical and medical sciences, offering capabilities in light microscopy, image analysis, and data management. The majority of the microscopes are set up with environmental control allowing long term imaging of live cells and model organisms.

Widefield fluorescence microscopy

Widefield fluorescence microscopy provides full-sample illumination and is ideal for imaging thin samples with high resolution. For thicker samples, deconvolution post-processing can enhance resolution and reduce noise. CAMDU offers multiple widefield systems for versatile applications. Available systems include:

• Nikon TI- Eclipse 2: High-performance systems designed for precision imaging including a multi-laser photo kinetics unit allowing FRAP and optogenetics experiments.

Spinning disk confocal microscopy

Spinning disk confocal microscopy uses laser illumination and pinhole arrays to eliminate out-of-focus light, making it ideal for high-speed, optically sectioned imaging. Available systems include:

• Andor SD: High-resolution imaging for dynamic processes with dual camera and FRAP unit

Total internal reflection fluorescence microscopy (TIRF)

TIRF microscopy is suited for visualising events within 100nm of the coverslip, providing unparalleled axial resolution for studies of cell membranes and protein interactions. Available systems include:

• Nikon TIRF: Optimised for advanced photokinetics studies.

Lattice light sheet microscopy

Light sheet microscopy provides excellent optical sectioning and minimal phototoxicity, making it perfect for live-cell imaging. CAMDU’s Lattice Light Sheet Microscope enables rapid, high-resolution imaging of dynamic biological systems with reduced photobleaching.

Point-scanning confocal microscopy

Point-scanning confocal systems provide highly precise optical sectioning and are ideal for thicker samples. Available systems include:

• Olympus FV3000: Advanced imaging for complex biological samples.
• Nikon AX-R with NSPARC: for super resolution imaging

Multiphoton microscopy

Multiphoton microscopy allows imaging deeper into tissues than confocal microscopy

• Olympus Multiphoton (MPE): Enables deep tissue imaging with minimal photodamage.

Specialist microscopes

CAMDU offers a range of cutting-edge specialist microscopes for your unique imaging needs. Available systems include:

• Quantitative Phase Imaging (QPI Telight Q-Phase): label-free cellular and tissue imaging.
• diSPIM Microscope: High-speed imaging with unmatched resolution.
• BioAFM: combining nm-scale topography measurement and mechanical measurements of live biological samples in liquid medium while simultaneously performing fluorescence microscopy

Other equipment

• Primo: Micropatterning, hydrogel polymerization and microfabrication
• Computational resources: CAMDU’s computational workstations are optimised for advanced image analysis and machine learning applications with high-performance CPU and GPUs. The workstations are equipped with advanced image analysis software. CAMDU’s image analysis specialist can provide support for obtaining quantitative results.

Contact us

Get in touch to discuss how CAMDU can support your research and innovation needs. Contact Claire Gerard, Warwick Scientific Services Manager: .

Visit the CAMDU website for further information and a full list of microscopes.