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Solid-State Nuclear Magnetic Resonance (SS-NMR)

NMR is non-destructive method providing information about chemical structure and dynamics with atomic resolution. In solid-state NMR, high-resolution spectra are obtained by the technique of magic-angle spinning (MAS) that involves rotating the sample at high rotation frequencies (up to 60,000 rotations a second) around an axis inclined at 54.7 degrees to the direction of the superconducting NMR magnetic field. NMR spectra are nucleus specific (e.g., a 1H or 13C NMR spectrum is obtained), with spectral resonances being differentiated on the basis of the NMR chemical shift, while through-bond connectivities and through-space proximities can be identified by means of experiments that utilise J and dipolar couplings between nuclei.

Applications:

Spectra can be obtained for most solids, e.g., pharmaceuticals, polymers, glasses, and biosolids. Notably, since NMR is a probe of the local (typically up to 0.5 nm) structure around a specific nucleus, there is no requirement for long-range periodic order, and solid-state NMR is readily applicable to disordered solids.

Sample Handling Requirements:

Powder, in favourable cases, spectra can be obtained for as little as a few mg. Variable temperature experiments are feasible over the range -140 to +150 C.

Complementary Techniques:

Solution-state NMR, XRD, EPR.

Warwick Capability:

7 solid-state NMR spectrometers (100-600 MHz, Bruker & Varian) as well as hosting the UK 850 MHz solid-state NMR facility.

Contact:

Dr Ian Hancox, 024 76 150380 email i dot hancox at warwick dot ac dot uk.

SSNMR

Typical results format, and sample:

Solid state NMR spectrum

Status
Availability

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