Ex Vivo Lung Biofilm Infection Model
- 3Rs compliant
- Respiratory pathogens
- Bacteria / fungi (in development) / viruses (in development)
- Specialised cystic fibrosis model available
- Other lung conditions may be available on request
- Detailed information
Antimicrobial Susceptibility Testing
- Minimum Inhibitory Concentration
- Minimum Bactericidal Concentration
- Minimum Biofilm Eradication Concentration
- Checkerboard Synergy
- Disk Diffusion
- Time-kill
- Post-Antimicrobial Effect
- E-test
Protein services
Mass spectrometric analysis.
- Test compounds before and after their exposure to target organisms to determine compound stability and/or metabolism
- Development of assays for target activity in vitro with potential inhibitors or in vivo with potential antimicrobials to assess on target activity as reported by target substrate accumulation
- Analysis of proteins where covalent modification by an antibiotic is suspected.
- Shelf life and stability studies
Toxicity testing
- Mammalian cell lines (diverse range of mammalian cell lines)
- Zebra fish
- Wax moth larvae
- Insect lines available
- Next Generation Sequencing
- Sanger Sequencing
- Microarrays
- Real time PCR
- World class GPC suite
- Surface energy / drop shape analysis
- Thermal analysis suite
- Polymer synthesis
Resistance Generation
- Sub-MIC Selection
- Mutation Rate Calculations
- Resistant mutants
- Genomic Sequencing
