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Antimicrobial Screening Facility (UK NEQAS accredited)

Pig bronchiole with bacterial biofilm

Ex Vivo Lung Biofilm Infection Model

  • 3Rs compliant
  • Respiratory pathogens
  • Bacteria / fungi (in development) / viruses (in development)
  • Specialised cystic fibrosis model available
  • Other lung conditions may be available on request
  • Detailed information

Toxicity

Antimicrobial Susceptibility Testing

  • Minimum Inhibitory Concentration
  • Minimum Bactericidal Concentration
  • Minimum Biofilm Eradication Concentration
  • Checkerboard Synergy
  • Disk Diffusion
  • Time-kill
  • Post-Antimicrobial Effect
  • E-test

Resistance

Protein services

Stability Testing

Mass spectrometric analysis.

  • Test compounds before and after their exposure to target organisms to determine compound stability and/or metabolism
  • Development of assays for target activity in vitro with potential inhibitors or in vivo with potential antimicrobials to assess on target activity as reported by target substrate accumulation
  • Analysis of proteins where covalent modification by an antibiotic is suspected.
  • Shelf life and stability studies

Mode of Action

Toxicity testing

  • Mammalian cell lines (diverse range of mammalian cell lines)
  • Zebra fish
  • Wax moth larvae
  • Insect lines available

Genomics

  • Next Generation Sequencing
  • Sanger Sequencing
  • Microarrays
  • Real time PCR

Polymer Characterisation

  • World class GPC suite
  • Surface energy / drop shape analysis
  • Thermal analysis suite
  • Polymer synthesis

Resistance Generation

  • Sub-MIC Selection
  • Mutation Rate Calculations
  • Resistant mutants
  • Genomic Sequencing