Dr Bernard Burke
Supervisor Details
Research Interests
Macrophages, Hypoxia, Cancer, Infection, Innate immunity, Biomaterials, Gene Expression.
My research focuses on gene expression changes in one of the key cells of the immune system, the macrophage. In particular I focus on responses to low oxygen (hypoxia), which is an important factor in cancer progression, and to infections. I am interested in how macrophages regulate transcription to modulate their gene expression in response to these stimuli, and how this knowledge can be used in combatting infections and cancer. I am also interested in the responses of macrophages to implanted biomaterials such as tooth implants and artificial hip joints, and how these can be modulated to improve patient outcomes.
Scientific Inspiration
Francis Crick, for his ability to investigate such different areas as the structure of DNA and the workings of the human brain.
MIBTP Project Details
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